Session Information
Date: Sunday, October 7, 2018
Session Title: Other
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To study the spectrum of clinical features of antineuronal antibody associated neurological syndromes presenting at a tertiary care centre in North India.
Background: Movement disorders are a prominent and common feature in many autoantibody-mediated neurological diseases and are encountered at any level of medical care. It is imperative not to miss these potentially treatable disorders, which can also be an alert to an occult neoplasia
Methods: 26 cases of prospectively recruited and followed up patients of antineuronal antibody positive neurological syndromes (cell based assays), from a tertiary care center in North India, were included. Demographic profile, clinical features, laboratory workup and neuroimaging findings were recorded. Categorical variables are analyzed as frequencies and ratios and continuous variables as mean and median.
Results: Mean age was 36.34±12.16 years, with a strong female preponderance (73.33%). Anti-NMDA receptor antibodies were the most common (Seven; 26.92%), followed by Anti LGI1 (twelve; 46.15%), Anti CASPR 2 (five; 19.23%) anti-basal ganglia antibodies (One, 06.66%) and Anti-Ri (One, 06.66%). Spectrum of movement disorders seen included generalized dystonia (57.69%), orofacial dyskinesia (eight; 30.76%), facio-brachial dystonic seizures (three; 11.53%), myoclonus (three; 11.53%), chorea (three; 11.53%) and parkinsonism (three; 11.53%). An associated malignancy was detected among four subjects.
Conclusions: An early diagnosis is important for the prognosis, yet many patients are misdiagnosed, or diagnosed late. A close observation and analysis of movement disorders may give an early clue as to the disorder in question
References: 1. Balint B, Vincent A, Meinck HM, Irani SR, Bhatia KP. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2018 Jan 1;141(1):13-36. 2. Balint B, Bhatia KP. Stiff person syndrome and other immunemediated movement disorders—new insights. Curr Opin Neurol 2016; 29: 496–506. 3. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091–8.
To cite this abstract in AMA style:
A. Kumar, S. Mehta, V. Lal. Spectrum of movement disorders with anti-neuronal antibodies: Case series [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/spectrum-of-movement-disorders-with-anti-neuronal-antibodies-case-series/. Accessed June 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/spectrum-of-movement-disorders-with-anti-neuronal-antibodies-case-series/