Objective: In the present study, we evaluate a prevalence of subjective cognitive complaints (SCC)in patients with progressive supranuclear palsy (PSP) as well as clinical features of PSP patients with SCC based on their cognitive status.

Background: SCC, refer to self-reported cognitive decline that may or may not be reflected in objective neuropsychological test results, is prevalent in Parkinson’s disease (PD). However, the prevalence and clinical features of SCC in PSP patients have not yet been investigated.

Method: We recruited 87 PSP patients with normal cognition (NC) or mild cognitive impairment (MCI) and investigated SCC using the semi-structured interview. Comprehensive neuropsychiatric tests were done and compared clinical features and the results of neuropsychiatric tests according to the present of SCC.

Results: Out of the 83 patients, 16 had normal cognition (NC) and 67 had MCI. Among the NC patients, 37.5% had SCC (6/16) and 44.8% (30/67) of MCI patients had SCC. When including both NC and MCI, 43.4% (36/83) of the patient with PSP had SCC. The demographics and clinical characteristics of the MCI+SCC and MCI-SCC were comparative. The MCI+SCC group had significantly worse score in neuropsychological tests in attention domain, language, and visual memory, fronto-executive function, compared with the who did not have SCC.

Conclusion: In conclusion, the present study found that SCC is common in PSP patients, and PSP with MCI+SCC had worse cognitive function than who did not have SCC. They might have more change to progress to dementia, therefore physicians should check the SCC in the PSP patients and try not to miss the timely diagnosis and management of cognitive impairment.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/subjective-cognitive-complaints-in-patients-with-progressive-supranuclear-palsy-and-corticobasal-syndrome/