Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The aim of this study is to determine if cerebral blood flow (CBF) reduction in the cerebellum could be a tool for differential diagnosis between patients with multiple system atrophy (MSA) and patients with Parkinson’s disease (PD).
Background: MSA is the neurodegenerative disease showing progressive atypical parkinsonism, which is frequently misdiagnosed as PD, especially in case without cerebellar symptom or atrophy. The accurate tool for differential diagnosis between MSA and PD could facilitate clinical trials of disease modifying therapy.
Methods: Twenty one patients with PD were diagnosed as clinically established PD or clinically probable PD (10 men and 11 women with a mean age of 67.7 ± 12.3 years), fifteen patients with MSA with predominant parkinsonian features (MSA-P), six patients with MSA with predominant cerebellar ataxia (MSA-C) were diagnosed as probable or possible MSA (11 men and 10 women with a mean age of 65.2 ± 9.3 years), fifteen patients with progressive supranuclear palsy (PSP) were diagnosed as probable or possible PSP (5 men and 10 women with a mean age of 73.7 ± 6.1 years) according to the internationally established criteria were included in this study. All patients underwent N-isopropyl-[123I] p-iodoamphetamine (IMP) single photon emission computed tomography (123I-IMP SPECT) and data were analyzed using three-dimensional stereotactic surface projection (3D-SSP) software. Area under curve (AUC) of receiver operating characteristic (ROC) of CBF reduction in the cerebellum was assessed.
Results: Cerebellar perfusion was significantly decreased in the MSA-P (P < 0.001, one-way ANOVA; P < 0.001, post hoc, Dunnett), MSA-C (P < 0.001, post hoc, Dunnett) compared with the PD. There was no difference in cerebellar perfusion between PSP and PD (P = 0.598, post hoc, Dunnett). Specificity of CBF reduction in the cerebellum for MSA-P vs PD was 1.00, while sensitivity was 0.67. CBF reduction may be an optimal tool for differentiating between MSA-P and PD (AUC = 0.849).
Conclusions: In conclusion, our findings suggested that CBF reduction in the cerebellum using 123I-IMP SPECT could be a useful tool for differentiating between MSA-P and PD.
To cite this abstract in AMA style:
N. Murakami, W. Sako, S. Haji, Y. Izumi, R. Kaji. The difference in cerebellar blood flow reduction in multiple system atrophy and Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/the-difference-in-cerebellar-blood-flow-reduction-in-multiple-system-atrophy-and-parkinsons-disease/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-difference-in-cerebellar-blood-flow-reduction-in-multiple-system-atrophy-and-parkinsons-disease/