Objective: Sustained Effects of Apomorphine infusion on Head Ptosis, a case report

Background: IntroductionHead ptosis (Hp) results from weakness of the neck extensor, or increased tone of the flexor muscles1. Hp can be caused by specific generalized neuromuscular diagnoses, MG, ALS or polymyositis. Sometimes Hp is seen in association with camtocormia.Definite pathophysiological diagnose is often not possible. It can be a part of PS with a reported prevalence of 3 to 17,6%

Method: Intermittent infusion with apomorphine (Daceptone™) showed  positive effects on  Hp and pump therapy 16h/day was initiated.

Results: Longstanding effects were seen >2 months, so far.

Conclusion: Apomorphine infusion therapy can be considered in patients suffering from severe Head drop as a part of a parkinsonian syndrome.

References: References: 1. Abe K, Uchida Y, Notani M. Camptocormia in Parkinson’s disease. Parkinsons Dis. 2010;2010. 2. Umapathi T, Chaudhry V, Cornblath D, Drachman D, Griffin J, Kuncl R. Head drop and camptocormia. Journal of Neurology, Neurosurgery & Psychiatry. 2002;73(1):1. 3. Margraf NG, Wrede A, Deuschl G, Schulz-Schaeffer WJ. Pathophysiological Concepts and Treatment of 2015;122(6):835-9. Camptocormia. J Parkinsons Dis. 2016;6(3):485-501. 4. Mensikova K, Kaiserova M, Vastik M, Kurcova S, Kanovsky P. Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study. J Neural Transm (Vienna).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-effects-of-apomorphine-infusion-on-head-ptosis-a-case-report/