Objective: The aim of this study is to make a Turkish adaptation of the “Gastrointestinal Dysfunction Scale for PD (GIDS-PD)”and detect gastrointestinal symptoms at an early stage and evaluate their relationship with patient characteristics.

Background: Gastrointestinal dysfunction is a common premotor and nonmotor symptom that is involved in the pathogenesis of Parkinson’s disease (PD). Gastrointestinal symptoms are related to patient demographic characteristics, disease type, prognosis, and treatment response. GIDS-PD scale includes three subdomains: Constipation, Bowel Irritability and Upper GIS. GIDS-PD is the first and only scale that questions complaints specific to the gastrointestinal system in Parkinson’s patients in detail.

Method: One hundred twenty Parkinson’s patients and 60 controls were included. Translation permission received from MDS. Participants were assessed using the Turkish version of SCOPA-AUT, Non- Motor Symptoms Questionnaire (NMSQuest-TR), Hospital Anxiety and Depression Scale (HADS), and Gastrointestinal Dysfunction Scale for Parkinson’s Disease (GIDS-PD-TR), H&Y and UPDRS Part 3. Demographic characteristics and disease features of the patients were evaluated.

Results: GIDS-PD-TR was found to be valid and reliable (Cronbach’s alpha value= 0.837; test-retest stability, ICC=0.972). A high positive correlation was detected between GIDS-PD-TR and the reference scales [table1]. The cut-off value for GIDS-PD-TR Constipation subscore was found as ≥6 in the ROC analysis [table2] and constipation was detected in 54% of our patients. GIDS-PD-TR scores were found to be higher in Parkinson’s patients than in healthy controls [table3].  A statistically significant positive correlation was found between the patient’s age at diagnosis, current age, disease duration, LEDD, UPDRS Part 3 score, H&Y stage and GIDS-PD-TR Total score [table4]. On the other hand, no significant correlation was found between gender, disease pattern, disease duration, smoking, alcohol, antidepressant use.

Conclusion: Turkish adaptation of the GIDS- PD scale is valid and reliable. GIDS-PD-TR score was found to be higher in PD patients who are older, have late disease onset, long disease duration, high LEDD, and severe disease.

Table1

Table2

Table3

Table4

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MDS Abstracts - https://www.mdsabstracts.org/abstract/turkish-validity-and-reliability-study-of-the-gastrointestinal-dysfunction-scale-for-parkinsons-disease/