Loss of FBXO7 (PARK15) leads to disturbances in proteasomal function and models parkinsonism-like and pyramidal symptoms in mice
Objective: To model Parkinsonian-pyramidal syndrome (PARK15) in mice and investigate the impact of loss of F-box only protein 7 (FBXO7) in neurons on proteasomal activity.…Initial clinical description of progressive supranuclear palsy in the Luxembourg Parkinson’s study
Objective: To characterize the clinical features and prevalence of patients with progressive supranuclear palsy (PSP) in the recently implemented longitudinal Parkinson's cohort (HELP-PD). Background: PSP…Comparative analysis of freezing of gait in distinct parkinsonism types by diffusion tensor imagining and cognitive profiles
Objective: To demonstrate possible disturbances in pedinculopontine nucleus (PPN) and its connections in freezing of gait (FOG) by DTI in conjunction with the cognitive profile.…Sleep deprivation (SD) amongst carers of patients with Parkinson’s disease (PD)
Objective: To identify nocturnal symptoms in patients which lead to sleep deprivation in carers of PD patients. Background: SD affects the health status of the…Hypothalamic alpha-synuclein pathology and its relation to non-motor symptoms and disease progression in Parkinson’s disease
Objective: To assess alpha-synuclein pathology and tyrosine hydroxylase (TH) immunoreactivity as a dopaminergic marker in three hypothalamic nuclei with potential clinical implications (paraventricular, supraoptic and…Chronic levodopa treatment accelerates the disorders of circadian rhythm in 6-OHDA induced Parkinson’s disease model
Objective: We aimed to study the effect of levodopa on circadian rhythms in 6-OHDA lesioned rats, and to clarify whether the disturbance of the circadian…Idiopathic Parkinson’s disease presenting with dysphagia 15 years before PD diagnosis
Objective: To describe an atypical presentation of Idiopathic Parkinson's disease. Background: Dysphagia is a commonly reported “non-motor” feature of Idiopathic Parkinson's disease (IPD), which usually…Anxiolytic-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) in rodent models of anxiety
Objective: The aim of this study was to assess the anxiolytic effects of istradefylline (KW-6002), an adenosine A2A receptor antagonist, in naive and anxiety-prone animals…Measurement of night time sleep using an accelerometry based system
Objective: To establish whether accelerometry using the Parkinson Kinetigraph (PKG, Global Kinetics) can distinguish between normal and abnormal nocturnal sleep in Parkinson's disease (PD). Background:…Exploring association of GBA variants with pre-diagnostic features of PD in the PREDICT-PD cohort: A nested case-control study
Objective: To investigate the association of GBA variants with pre-diagnostic features of Parkinson's disease (PD) within the PREDICT-PD cohort. Background: Subtle motor and non-motor symptoms…
- « Previous Page
- 1
- …
- 104
- 105
- 106
- 107
- 108
- …
- 207
- Next Page »