MANF protects dopamine neurons and locomotion defect from Neurotoxin/Human alpha-synuclein-induced progressive Parkinson’s disease models in C.elegans.
Objective: To study whether Mesencephalic astrocyte-derived neurotrophic factor (MANF) has beneficial effects in parkinson disease and its intracellular mechanisms. Background: The distinguishing feature of Parkinson’s…Decisional capacity for Goals of Care in Parkinson’s Disease with Cognitive Concerns
Objective: We sought to assess decisional capacity (DC) for Goals of Care (GOC) using the MacArthur Competence Assessment Tool (MacCAT) for Parkinson’s disease (PD) patients…Validation of Computerised Measures of Executive Functioning for use in Parkinson’s Disease Assessments.
Objective: i. To validate the use of a computerised finger tapping task as a screening measure for Executive Dysfunction (EF) in Parkinson’s Disease (PD), against…Subcortical involvement in phonological input processing: an electrophysiological registration study
Objective: The current study applied direct electrophysiological registration of the local field potential activity in the thalamus, subthalamic nucleus (STN) and the pedunculopontine nucleus (PPN)…Intention Awareness in Parkinson’s Disease
Objective: To investigate the role of dopamine in intention awareness of voluntary actions in patients with Parkinson’s Disease (PD). Background: Underactivation of the SMA due…Classification of neurocognitive impairment in Spanish speaking Parkinson’s disease patients
Objective: To examine differences between United States (US) and Latin American (LA) norms classifying cognitive impairment using standardized neuropsychological measures to assess cognition in Parkinson’s…Caffeinated Drinks, LRRK2 Genotype and PD
Objective: To determine the role of caffeine containing drinks on penetrance in LRRK2-associated PD Background: LRRK2 penetrance is reduced for PD [1]. Environment and/or other…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2 -related Parkinson’s disease
Objective: Our study aimed to evaluate neuromelanin-Magnetic Resonance signal changes in PD patients carrying a LRRK2 mutation. Background: Specific magnetic resonance (MR) sequences are able to…Are there genotype-phenotype correlations in Perrys syndrome?
Objective: To examine genotype-phenotype correlations in a cohort of three patients with Perrys syndrome. Background: Perrys syndrome is a rare cause of familial parkinsonism. Since the…
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