Cerebrospinal fluid biomarkers in Huntington’s disease – a longitudinal study
Objective: To validate the role of NFL as a marker of disease progression and to discover new biomarkers in HD. Background: Neurofilament light chain (NFL)…Prescription pattern of treatment in Mexican patients with Huntington’s Disease.
Objective: To describe the prescription pattern for the treatment of HD in a sample of Mexican patients from a tertiary referral center. Background: Huntington’s disease…Longitudinal study of freezing of gait in patients with Parkinson’s disease
Objective: We conducted a prospective hospital based cohort study to investigate the incidence of Freezing of gait (FOG) and variables associated with onset of FOG…Modeling Parkinson’s disease pathology by combined injection of fibrilar and monomeric α-synuclein in rat brain
Objective: Development of a fast and progressive Parkinson’s disease (PD) model in rat Background: α-Synuclein is a common link between sporadic and familial PD. Rodent…Successful passive monitoring of early-stage Parkinson’s disease patient mobility in Phase I RG7935/PRX002 clinical trial with smartphone sensors
Objective: Smartphone-based assessments and sensors have the potential to enable remote, passive monitoring of gait and mobility in early-stage Parkinson’s disease (PD) patients. Such sensor…Parkinson’s Disease-Like Pathology in the Rat Brain and Colon Following Methamphetamine Self-Administration
Objective: To determine if Parkinson’s disease (PD)-like pathology occurs in brain and colon following termination of methamphetamine (meth) self-administration. Background: Meth abuse increases the risk…Inhibition of mitochondrial complex I synthesis by chloramphenicol mitigates dopaminergic neuronal cell loss in PQ-induced parkinsonism
Objective: To find the potent drug for prevention of PD, we screened with above 1000 drugs in the PQ treated cells which currently used drug…Salivary Alpha-Synuclein in Aging
Objective: We measured alpha-synuclein total (a-syntotal) and alpha-synuclein oligomers (a-synolig) concentration in 70 healthy subjects, of different ages (from 18 to 88 years old) to…Insulin Resistance In Non-Diabetic People With Parkinson’s Disease
Objective: To study the incidence of insulin resistance (IR) in people with Parkinson's Disease (PD) and its relationship with motor and non-motor symptoms of the…Perrault syndrome: CLPP-Knock-Out mouse brain shows accumulation of mitoribosomes
Objective: We aimed to document the alterations of pathways and molecules that underlie brain pathology in the Perrault syndrome. Background: Perrault syndrome is an autosomal…
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