Innovative recruitment strategies accelerate enrollment of genetic mutation carriers in the Parkinson’s Progression Markers Initiative (PPMI)
Objective: Determine feasibility of digital recruitment strategies, centralized screening, and a dedicated referral coordinator to enroll participants with LRRK2 or GBA mutations into PPMI, a…Randomized Parkinson’s Trial of GDNF Administered via Intermittent Intraputamenal Convection-Enhanced Delivery.
Objective: Assesing the neurorestorative effect of GDNF. Background: GDNF is a potent neurotrophic factor. A previous placebo-controlled trial, however, at 6 months, failed to demonstrate…Feasibility of using a smartphone application for the objective evaluation of Parkinson disease
Objective: To determine the feasibility, reliability, and value of using a smartphone application to longitudinally track motor and non-motor features of Parkinson disease (PD). Further,…Anxiety influences the neural correlates associated with freezing of gait in Parkinson’s disease
Objective: To evaluate whether Anxious Freezers have altered brain activity during FOG episodes compared to Non-Anxious Freezers. Background: A growing amount of research has emphasized…Altered attentional brain network in Parkinson’s disease with mild cognitive impairment
Objective: To investigate alterations in the attention network in Parkinson’s disease patients with mild cognitive impairment (PD-MCI). Background: MCI is a risk factor for dementia…Altered intrinsic brain functional connectivity in drug-naïve Parkinson’s disease with LRRK2 mutation
Objective: This study aimed to compare the alterations in the cortico-striatal functional connectivity (FC) of drug-naïve Parkinson’s disease (PD) patients with the leucine-rich repeat kinase…Grey matter abnormalities associated with early cognitive decline in Parkinson’s disease
Objective: To identify patterns of grey matter (GM) abnormalities in patients with Parkinson's disease (PD) with different cognitive profiles. Background: Cognitive symptoms occur already in…Brain PET metabolic substrate of Impulse Control Disorders in Parkinson’s Disease
Objective: The aim of this study was to describe the cerebral metabolic PET substrate and related connectivity changes in Parkinson's disease patients with impulse control…Substantia nigra area evaluated by neuromelanin-sensitive MRI as an imaging biomarker of disease progression in Parkinson’s disease
Objective: to investigate the pattern of substantia nigra - neuromelanin (SN-NM) area loss and contrast ratio (CR) intensity changes in late-stage Parkinson’s disease (LSPD) patients,…The involvement of primary olfactory cortex in olfactory deficits in early-stage Parkinson’s disease
Objective: To determine if the primary olfactory cortex (POC) is involved in the olfactory deficits in early-stage Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI)…
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