Clinical and genetic analysis of ataxic patients with CACNA1A mutations in Taiwan
Objective: To study the clinical presentation of ataxic patients with CACNA1A mutations in a Taiwanese cohort. Background: Mutations of CACNA1A gene is the genetic cause…Huntington’s Disease: Determinants for Cognitive Disease Progression – A Proposed Model
Objective: To develop a conceptual model to determine the rate of cognition impairment in Huntington's disease manifest patients and to identify the factors that influence…Dopamine transporter scan finding in patients with chorea.
Objective: To evaluate dopamine transporter scan findings in patients with chorea. Background: Chorea is nonrepetitive irregular involuntary movement with distal predominance. They are caused by…Admission Diagnoses and Eventual Discharge Dispositions for Hospitalized Huntington’s Disease Patients: Results of a Nationwide Survey
Objective: To better understand the causes of acute illness and its consequences for subsequent inpatient care in patients with Huntington’s Disease (HD). Background: HD is…Fundamental limit of the alpha-synuclein immunohistochemistry using the endoscopic biopsy from the gastrointestinal tract as a biomarker for Parkinson disease: a case-control study
Objective: To investigate significance of the Lewy pathology in biopsy and surgical specimen in the gastrointestinal (GI) tract as an in-vivo biomarker for Parkinson disease (PD). Background: Alpha-synuclein…Neuroinflammation in the substantia nigra is triggered by synucleinopathy and precedes nigral degeneration
Objective: To determine the relationship between synucleinopathy, neuroinflammation and nigrostriatal degeneration using the rat α-syn PFF model. Background: No therapy exists to halt or slow…Is the GBA2 a new modifier for Gauchers’s disease and GBA1-related Parkinson’s disease?
Objective: This study was performed to determine the pathological role of GBA2 in the central nervous system(CNS) in Gaucher’s disease (GD) and GBA1-related Parkinson’s disease…Beneficial and Protective Effects of Withania Someniferais On Mice Brain: A Therapeutic Potential Drug for Parkinson’s Disease
Objective: Objective of our study was evaluate effect of Withania Someniferais leaves on Parkinsons brain of mice Background: Parkinson’s disease (PD), an age-related disorder, is…Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Eight contact LFP recordings in the Subthalamic region localize beta source to the dorsal STN
Objective: The aim of this study was to investigate the electrophysiological characteristics of intra and extra STN LFPs in PD to better locate the source…
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