Citrus extract A protects dopaminergic neuron by modulating mitochondrial respiration and reactive oxygen species
Objective: This study aims to validate the protective effect of citrus extract A (CEA) against loss of dopamine neurons in PD by dual targeting of…Dynamic stability during turning in people with Parkinson’s disease
Objective: The goal of this study is to determine the contributions of dyskinesia to abnormal turning mechanisms. Background: The ability to turn safely while…Antibody binding differences in alpha-synuclein from Parkinson’s disease and multiple system atrophy
Objective: Determine whether alpha-synuclein derived from Parkinson's disease (PD) and multiple system atrophy (MSA) brains has different conformations as defined by biochemical and antibody-based approaches. Background: There…Optimization of Synucleinopathy and Nigrostriatal Degeneration Induced by Injection of Alpha-Synuclein Preformed Fibrils into Rat Striatum
Objective: Optimization of the surgical parameters (intrastriatal placement and concentration of alpha-synuclein preformed fibrils; α-syn PFFs) to increase the magnitude of nigrostriatal α-syn pathology and…Multivariate analysis of writer`s cramp: a study with advanced multi-channel microelectrode recording system
Objective: To quantify difference in WC patients with Concordant mirror movements(MMs) from those with Discordant MMs. Background: Invasive methods are encouragive for quantitative analysis. The…Idiopathic acquired sporadic (non-wilsonian) Hepatocerebral degeneration
Objective: To describe case series of patients with acquired hepatocerbral degeneration of idioapthic cause Background: Acquired (non-wilsonian) Hepato cerebral degeneration (AHD) is a rare neurologic…The Role of Clinical Outcome Assessment (COA) Data in the Drug Approval Process of Medicines for the Treatment of Restless Legs Syndrome (RLS): A Review of the Labels of Medicines Approved by the FDA and the EMA
Objective: The objectives of this study were 1) to identify the medicines approved for the treatment of restless legs syndrome (RLS) by the Food and…Clinical feasibility of a wearable, conformable, sensor patch to monitor motor symptoms in Parkinson’s disease
Objective: 2-part pilot study to evaluate feasibility of a wearable sensor, the prototype NIMBLE system sensor patch, to assess motor symptoms in Parkinson’s disease (PD) patients.…Development of a prototype alpha-synuclein vaccine to induce T regulatory cells for the treatment of synucleonopathy
Objective: Test the hypothesis that combining humoral and immunosuppressive cellular asyn immunization will enhance asyn clearance, and reduce inflammation and neuropathological symptoms in a human…Dopamine replacement medication improves acquisition, retention, and transfer of skilled upper extremity movement in people with Parkinson Disease.
Objective: To determine whether i) dopamine replacement medication affects learning of an upper limb (UL) feeding task in people with Parkinson disease (PD), and ii) training…
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