Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2 -related Parkinson’s disease
Objective: Our study aimed to evaluate neuromelanin-Magnetic Resonance signal changes in PD patients carrying a LRRK2 mutation. Background: Specific magnetic resonance (MR) sequences are able to…Are there genotype-phenotype correlations in Perrys syndrome?
Objective: To examine genotype-phenotype correlations in a cohort of three patients with Perrys syndrome. Background: Perrys syndrome is a rare cause of familial parkinsonism. Since the…Suicidality in Parkinson’s Disease: A Case Control Study
Objective: To investigate suicidality in Parkinson's disease (PD) by a case control study Background: Depression, a risk factor for suicidality, is rather common in PD patients. Nevertheless,…Movement Disorders secondary to Spinal Cord Demyelination: an Evolving Spectrum
Objective: To describe the spectrum of movement disorders that result from spinal cord demyelination. Background: Spinal movement disorders (SMDs) secondary to cord demyelination are not…Assessing Bone Health in Parkinson’s – When and how?
Objective: To assess the impact of, and practicality of, assessing bone health routinely in people newly diagnosed with Parkinson’s disease in a South Wales University…Corticobasal syndrome due to brain tumor
Objective: To describe a case of a 60-year-old female that presented with cognitive decline and gait disorders for the last 7 years. Background: The…Effect of early AbobotulinumtoxinA (Dysport®) use after stroke on the time to reach reinjection criteria: asymptomatic versus symptomatic patients
Objective: To determine if early post-stroke (within 12 weeks) abobotulinumtoxinA (aboBoNT-A;Dysport®) injections delay appearance or progression of upper limb symptomatic spasticity. Background: Muscle tone changes…MitoQ and Reduced Glutathione Protects Against Dopamine Induced Brain Mitochondrial Electron Transport Chain Inhibition During Extended In Vitro Incubation: Involvement of Free Radicals and Quinone Products
Objective: To study the impact of MitoQ and GSH against DA induced rat brain mitochondrial electron transport chain inhibition during extended in vitro incubation. Background:…PROMESA: Progression Rate of MSA under EGCG Supplementation as anti-Aggregation-Approach – evaluation of serious adverse events
Objective: In the PROMESA trial (ClinicalTrials Identifier: NCT02008721) Epigallocatechingallate (EGCG) a catechine that prevents pathological protein aggregation in vitro and can be purified from green…
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