DaTscan in clinical evaluation of Multiple System Atrophy
Objective: To explore accuracy of DaTscanTM Ioflupane I123 Injection (DaTscan) in a multiple system atrophy (MSA) cohort Background: There are isolated cases of normal DaTscan in neuropathologically confirmed MSA-cerebellar subtype (MSA-C)…The clinically-available anti-depressant mirtazapine alleviates both psychosis and dyskinesia in the MPTP-lesioned marmoset
Objective: To determine the effect of mirtazapine, a clinically-available anti-depressant, on psychosis and dyskinesia in Parkinson’s disease (PD). Background: Psychosis and dyskinesia cause significant morbidity…Impaired cerebellum to motor cortex associative plasticity in patients with spinocerebellar ataxia type 3
Objective: This study aims to investigate the associative plasticity induced by cerebellum to primary motor cortex (CB-->M1) corticocortical paired associative stimulation (PAS) in patients with…Dopamine replacement influences on postural motor learning in Parkinson disease
Objective: To determine if i) dopamine replacement affects general and sequence specific learning of a postural task in people with Parkinson disease (PD), and ii)…Sleep architecture in Parkinson´s disease and Parkinson’s disease associated dementia
Objective: To evaluate the differences in early sleep architecture between patients with Parkinson’s disease (PD) and Parkinson’s disease associated dementia (PDD). Background: Disorders of sleep…Cognition in the PREDICT-PD Cohort
Objective: To identify whether there is evidence for cognitive dysfunction in participants identified as being at higher risk of Parkinson’s disease (PD) using the PREDICT-PD…Fluency boost from walking in Parkinson’s disease
Objective: Examine the impact of a motor task on verbal fluency in individuals with Parkinson’s disease (PD) Background: Dual-tasking, in which individuals engage simultaneously in…TMEM230 mutation analysis in Parkinson’s disease in a Chinese population
Objective: To investigate the prevalence of TMEM230 mutations in Chinese patients with familial and sporadic PD. Background: Recently, Hanxiang Deng and colleagues identified a missense…SNCA multiplication consortium: Clinicogenetic analysis of SNCA multiplication probands and families.
Objective: Clinicogenetic analysis of 57 affected probands with SNCA multiplication, 3 unaffected carriers, and their 60 families. To use informative pedigrees to identify penetrance modifiers…The identification of molecular-genetic background of familial atypical parkinsonism in “Hornacko”, a specific region of the south-eastern Moravia, Czech Republic.
Objective: To assess the genetic background in the pedigrees with identified autosomal-dominant inheritance of parkinsonism. Background: Increased prevalence of parkinsonism with cognitive deterioration was detected…
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