Design of a Pharmacokinetics Study with Multiple Doses of Accordion Pill™ Carbidopa/Levodopa in Patients with Parkinson’s disease
Objective: To perform a pharmacokinetic (PK) study of the Accordion Pill™ carbidopa/levodopa (AP-CD/LD) and to determine if multiple doses can provide continuous delivery of LD.…Effect of exercise on neurodegenerative parkinsonism unmasked by dopamine blocking drugs (DRBD)
Objective: To test whether aerobic walking influences clinical status, biochemical and radiologic markers associated with degenerative parkinsonism unmasked by DRBD. Background: Failed trials of putative…Home based exercises to reduce falls in people with Parkinson’s disease: A randomized trial
Objective: To measure the outcomes of a six week, twice weekly, home physiotherapy exercise and falls education program on falls, mobility and quality of life…A controlled trial of ParkinSong singing groups to improve communication and wellbeing in Parkinson’s disease
Objective: To explore the effects of a therapeutic group singing intervention (ParkinSong) on communication and wellbeing outcomes for people living with Parkinson's disease. Background: Communication…Effective physiotherapy program for Parkinson’s disease
Objective: We developed new programs for mild and advanced stage of Parkinson’s disease (PD) patients, because the limited number of established PD program is now…CLOVER-DBS: A Prospective, Multi-center Clinical Study with Blinding to Evaluate a Closed Loop Programming Algorithm for Directional Leads Based on External Feedback
Objective: To assess the feasibility and efficacy of a novel closed-loop programming algorithm (CLPA) for directional lead deep brain stimulation (DBS) based on objective feedback…Effects of Korean Medicine on Postural Instability and Gait Difficulty in Patient with Parkinsonism
Objective: The purpose of this study was to investigate the effects of Korean Medicine on postural instability and gait difficulty (PIGD) in patient with parkinsonism.…Treatment of Levodopa Dose Failure with Subcutaneous Apomorphine Injection
Objective: We evaluated a subset of patients who were enrolled in the AMIMPAKT trial of sc apomorphine injection to treat morning akinesia (see reference) who…Does altering medication to avoid dyskinesia positively alters the breadth of the motor repertoire of patients with Parkinson’s disease? A pilot study
Objective: The aim of this study was to assess the level of drug-induced dyskinesia (DID), the presence of other motor symptoms of PD, and the…The Akt/mTOR/P70S6K/4EB-P1 signaling pathway is activated by metformin in a toxin-induced cellular model of Parkinson’s disease
Objective: To investigate the effects of metformin on the Akt/mTOR/P70S6K/4EB-P1 signaling pathway in a cellular model of Parkinson’s disease (PD). Background: Metformin is a drug…
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