The anti-dyskinetic effect of the clinically-available 5-HT3 receptor antagonist granisetron in the 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To determine the effect of the serotonin 3 (5-HT3) receptor antagonist granisetron, a clinically-available anti-emetic, on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia. Background: Dopamine replacement with L-DOPA…Relationship between Patient Global Impression of Change and other Efficacy Endpoints in Parkinson’s Disease: A post-hoc analysis from combined BIPARK-I and II
Objective: To evaluate the association of patients’ perception of Parkinson’s Disease (PD) symptoms improvement (as assessed by Patient Global Impression of Change, PGIC) could be…The combined effect of repetitive transcranial magnetic stimulation and treadmill training in people with Parkinson’s disease – A randomized controlled trial
Objective: To evaluate the combined effect of repetitive transcranial magnetic stimulation (rTMS) on treadmill training in people with Parkinson’s disease (PD). Background: Previous studies showed…DIRECT DBS: A Prospective, Multicenter Clinical Study with Double-Blinding for a Directional Deep Brain Stimulation Lead – Visualization of Optimal Directionally Stimulated Anatomy
Objective: To visualize the volumes of activated tissue in relation to the neuroanatomy for the optimal stimulation parameters in Ring Mode (omnidirectional) stimulation in comparison…Quantitative assessment of the effectiveness of adaptive Deep Brain Stimulation in Parkinson’s disease
Objective: To determine the effectiveness of Adaptive Deep Brain Stimulation (aDBS) in PD patients compared to cDBS and non-medicated PD patients (OFF). Background: aDBS based…The Effect of Conduction Exercise and Self-acupressure in Treatment of Parkinson’s Disease: A Pilot Study
Objective: To evaluate the efficacy and safety of exercise regime combining Conduction exercise (CE) and self-acupressure (SA) in treating both motor symptoms (MS) and non-motor…Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Does motor laterality affect the development of dyskinesia in patients with Parkinson’s disease?
Objective: To investigate the effects of motor laterality on the development of levodopa-induced dyskinesia (LID) in patients with de novo Parkinson’s disease (PD). Background: LID…Levodopa induced dyskinesia is preventable (15 years experience using continuous dopaminergic stimulation)
Objective: To evaluate whether levodopa induced dyskinesia is preventable in the treatment of patients with Parkinson’s disease. Background: Dyskinesia is one of the major complications…Magnetic resonance imaging-guided focused ultrasound unilateral pallidotomy for Parkinson’s disease: A report of 2 patients
Objective: To present two patients of Parkinson’s disease (PD) with Magnetic resonance imaging-guided focused ultrasound (MRgFUS) unilateral pallidotomy. Background: MRgFUS is a new technology that…
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