Neurorestorative effects of glycine transporter 1-inhibitor and D-Serine in a mouse model of nigrostriatal dopaminergic degeneration
Objective: We set out to evaluate potential neurorestorative effects of the GlyT1 inhibitor ACPPB vis-à-vis D-Serine in the intrastriatal 6-OHDA mouse model of Parkinson’s disease.…The NIC-PD-study –A randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson‘s disease in Germany and N. America
Objective: To evaluate the disease modifying potential of transdermal (TD) nicotine in early Parkinson’s disease (PD). For this explanatory purpose, the primary endpoint was the…Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry
Objective: This four-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring…Impulse control disorders could be accompanied by hypomanic state under intestinal levodopa infusion
Objective: To determine characteristics of parkinsonian patients under levodopa/carbidopa intestinal gel (LCIG) infusion who present impulse control disorders (ICDs). Background: ICDs may be induced by…Speech Intelligibility in Parkinson’s disease following Intensive Voice and Articulation Treatments
Objective: Our aim was to evaluate the impact of voice treatment (LSVT LOUD) and articulation treatment (LSVT ARTIC) on speech and consonant intelligibility in Parkinson's…A single center retrospective analysis of Opicapone treatment in 90 Parkinson patients
Objective: To evaluate retrospectively the treatment with the novel COMT-inhibitor opicapone (OPC) in a tertiary Parkinson Center the first year after its approval in Germany…Persistent downbeat nystagmus due to Arnold-Chiari type I malformation
Objective: Describe a patient with persistent downbeat nystagmus(DBN) related to Arnold-Chiari type I malformation Background: As a rare acquired nystagmus with various causes, DBN is…Pediatric Tics and DCD: Motor Network Disorders?
Objective: To characterize and quantify pediatric tics and DCD according to specific movement disorder features. Background: Until now, it has been impossible to attribute the…Neurological improvement with WTX101 treatment in a Phase 2, multi-center, open label study in Wilson Disease
Objective: The objective of this study was to characterize neurological manifestations in Wilson Disease (WD) patients and describe specific neurological changes after 24 weeks’ treatment…Deep brain stimulation outcomes for primary and secondary dystonia
Objective: To describe clinical outcomes of pallidal stimulation in different types of dystonia, both primary and secondary and long-term results. Background: Many studies have previously…
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