Semi-automated segmentation and quantification of the substantia nigra depigmentation in Parkinson’s disease – a multicentre case control MRI study in 284 participants
Objective: To provide a semi-automated segmentation and quantification method of the changes in the substantia nigra (SN) in Parkinson’s disease (PD) using neuromelanin (NM)-sensitive MRI…Unilateral abnormal dopamine transporter (DaT) scans: Early indicator of Parkinson’s disease and degenerative Parkinsonism
Objective: In this study, we aimed to determine the relevance of unilateral abnormal dopamine transporter (DaT) scans in patients presenting with clinically uncertain Parkinsonian syndromes…Microstructural Abnormalities in Drug-naïve Parkinson’s Disease with Mild Cognitive Impairment: A Diffusion Tensor Imaging Study
Objective: The aim of this study was to use MR diffusion tensor imaging to investigate the brain microstructural alterations in newly diagnosed drug-naïve Parkinson’s disease…Efficacy of incobotulinumtoxinA in patients with sialorrhea, as assessed using the modified Radboud Oral Motor Inventory for Parkinson’s disease (mROMP): Results of the SIAXI study
Objective: The pivotal double-blind, randomised Phase III SIAXI study (NCT02091739), assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U for sialorrhea. Co-primary endpoints…Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder
Objective: Study the relationship between RBD and other symptoms of PD. Background: Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two…Striatal dopamine transporter availability changes reflect gastrointestinal dysautonomia severity in early Parkinson’s disease
Objective: To test the hypothesis that constipation and gastrointestinal (GI) dysautonomia may be correlated with nigrostriatal dopaminergic (DA) dysfunction in PD. Background: Constipation is a…Sensory signs and neuropathic pain in advanced Parkinson’s disease under levodopa treatment
Objective: To evaluate whether patients affected by Parkinson’s disease (PD) under levodopa/carbidopa intestinal gel (LCIG) therapy have alterations in sensory symptoms and signs and/or painful…The Clinical Research of Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
Objective: To compare the differences of clinical characteristics between PD patients with rapid eye movement sleep behavior disorder (RBD) (RBD+ group) and those without RBD…Is Heart Rate variability a differential biomarker in REM sleep behavior disorder, Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy?
Objective: Heart rate deceleration capacity (DC) and heart rate variability index (HRVI) as potential biomarkers for autonomic dysregulation were studied in subjects (each group N=10)…Olfactory Hallucinations as a Non-motor sign of Parkinson’s disease – A cross-sectional study amongst patients in a tertiary movement center
Objective: Assess the prevalence of olfactory hallucinations (OlfH) in patients presenting to a tertiary movement disorders outpatient clinic. Background: Hallucinations can be considered a non-motor…
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