Selection of odorants for diagnosis of Parkinson’s disease
Objective: The goal of this study was to identify the subset of Sniffin Sticks Test odorants that could be used to differentiate patients with Parkinson’s…Preclinical cardiovascular sympathoexcitatory effects of TD-9855, a novel norepinephrine transporter (NET) inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension (nOH) in patients with primary autonomic failure
Objective: TD-9855 is a novel NET inhibitor (1) being studied for the treatment of symptomatic nOH. The objective of the present study was to characterize…Visual deficits of self-motion perception in Parkinson’s disease
Objective: To investigate unisensory and multisensory self-motion perception mediated by the visual and vestibular systems in PD. Background: Parkinson's disease (PD) is classically characterized by…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…Low body weight is associated with poor functional status in Parkinson’s disease (PD)
Objective: To assess if low body weight and malnutrition is associated with poor functional status in PD. Background: It has been observed that many advanced…Apathy in Parkinson’s disease is associated with abnormal alpha oscillatory behaviour during incentivized movement
Objective: To determine the relation between apathy and neural oscillations in Parkinson’s disease (PD). Background: Apathy in PD, characterized by lack of motivation, is often…Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: To characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD) subjects and compared to…Serum glutamate is associated with the motor subtype of Parkinson’s disease
Objective: We aimed to study the concentration of glutamate in the serum of patients with Parkinson's disease (PD) and its connection with clinical variants of…PrP as a receptor of alpha-synuclein in the pancreas of patients with synucleinopathies
Objective: We have investigated whether the cellular prion protein interacts with alpha-synuclein in pancreatic cells of patients with synucleinopathies. Background: Neurodegenerative diseases such as Alzheimer’s…Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
Objective: We hypothesize that cerebral hypoperfusion may influence the cognitive function of PD animal models. To investigate the effects of cerebral hypoperfusion and microangiopathy on…
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