Influence of baseline OFF-time in the efficacy response of opicapone in Parkinson’s disease patients with motor fluctuations: The BIPARK-I double-blind experience
Objective: To evaluate the efficacy of opicapone (OPC) in levodopa-treated Parkinson’s Disease (PD) patients with motor fluctuations and subdivided by their baseline OFF-time. Background: OPC,…A first-in-human clinical study to test the safety and preliminary efficacy of CDNF in Parkinson’s disease
Objective: To develop a novel disease-modifying therapy in Parkinson's disease (PD) that affects both motor and non-motor symptoms, based on a novel stress-protective protein CDNF.…Augmented Reality-Based Dance Application on Balance and Mobility of Individuals with Parkinson’s Disease: A Pilot Study
Objective: To investigate the acute and long-term effects of a mobile, augmented reality-based extension of Dance for PD® classes on balance and mobility in persons…Basal Ganglionic Lesions in Egyptian Children: Radiological Findings in Correlation with Etiology and Clinical Manifestations
Objective: to determine the etiology of basal ganglionic disorders in a sample of Egyptian children. Background: In childhood, the metabolic activity of the basal ganglia…Exosomal alpha synuclein secretion is beneficial for cellular models of Kufor-Rakeb syndrome
Objective: The purpose of this study is to investigate the effect of induction of exosomal a-syn secretion on PARK9-mediated neurotoxicity. Background: Kufor-Rakeb syndrome (KRS) is…Biological course and natural history of hereditary spastic paraplegia type 11 (SPG11)
Objective: We aim to establish biological markers for the natural history and course of hereditary spastic paraplegia (HSP) type 11 (SPG11) using multiple readout parameters…Patient with secondary dystonia treated with internal globus pallidus deep brain stimulation (GPi-DBS), 2 years results: A case report
Objective: To assess long term benefit of multiple source steering of GPi-DBS in a patient with secondary dystonia due to kernicterus related perinatal encephalopathy. Background:…Optimizing the Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) outcome in Parkinson’s disease patient with interleaving stimulation
Objective: To explore interleaving versus conventional stimulation in subthlalmic nucleus (STN) deep brain stimulation (DBS) in optimizing the effect. Background: STN DBS is effective for…Programming for Freezing of gait after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease
Objective: Freezing of gait (FOG) is a common gait disorder in Parkinson's disease (PD). In this study, we will adjust programming for patients with FOG…A prospective MRI study of edema surrounding deep brain stimulation leads
Objective: The purpose of our study is to define the incidence and the magnetic resonance imaging (MRI) characteristics of peri-electrode edema in a cohort of…
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