Differentiating the substantia nigra pars compacta and ventral tegmental area in early-stage Parkinson’s disease using quantitative susceptibility mapping
Objective: To assess iron levels in dopaminergic midbrain nuclei using quantitative susceptibility mapping for identification of biomarkers of PD. Background: The midbrain dopaminergic system plays…Effective deep brain stimulation co-modulate cross-frequency coupling
Objective: The disruption of pathological signals in the cortico-basal ganglia- network has been hypothesized as a mechanism of action of deep brain stimulation (DBS). However,…Neuronal Network Underlying Speech Difficulties in Parkinson’s Disease
Objective: We aimed to investigate whether speech difficulties are associated with changes in cortical thickness. Background: Speech difficulties are a common debilitating feature of Parkinson’s…Cortical cholinergic dysfunction correlates with microglial activation in the Substantia Innominata in patients with REM sleep behavior disorder
Objective: To explore possible correlations between levels of microglial activation (neuroinflammation) in the Substantia Innominata (SI), the major source of cholinergic input to the cortex,…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Huntington’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Huntington’s disease gene expansion carriers (HDGECs) using [11C]BU99008 PET, a novel radioligand with high specificity and…Park-Ease Trial: A Randomized Controlled Trial to Study the Efficacy of Exercises in Early-Stage Parkinson’s Disease
Objective: To evaluate the efficacy of exercises in early-stage Parkinson’s Disease by observing improvement in motor symptoms assessed by Unified Parkinson’s Disease Rating Scale (UPDRS)…Misdiagnosis in blepharospasm: the common imitators which should not be missed
Objective: Blepharospasm is a focal dystonia whose diagnosis is completely clinical with no blood or imaging biomarker. We observed that sometimes, patients with other disorders…Stiff-Person Syndrome and Limbic Encephalopathy Associated With GAD-antibody: A Case Report
Objective: To extend spectrum of glutamic acid decarboxylase(GAD) associated disorders by reporting a case Background: GADA associated disorders include a broad and clinically heterogeneous group…Satisfaction with care in late stage Parkinson’s disease
Objective: To assess satisfaction with care in patients with late stage Parkinson’s disease (PD) and to identify factors associated with patient satisfaction with care. Moreover,…Characterization of impulsivity in Colombian patients with Huntington’s disease
Objective: To describe impulsivity in patients with Huntington's disease using a self-report scale and through an objective test of the inhibition capacity. Describe the demographic…
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