Exploring anti-hypertensives as possible disease modifying agents in Parkinson’s disease using artificial intelligence and epidemiology
Objective: To apply machine learning and epidemiology to identify existing drugs that may have a disease modifying effect in Parkinson’s disease (PD). Background: Drug repurposing…Ataxia with(out) oculomotor apraxia: A unique SETX mutation in 3 siblings
Objective: Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal recessive cerebellar ataxia due to SETX gene mutation characterized by progressive cerebellar atrophy, neuropathy,…Evolution of ataxia in risk persons for spinocerebellar ataxia (SCA)
Objective: To study the premanifest stage of the most common SCAs. Specifically, we wanted to determine the conversion rate to ataxia in risk persons and…A case of cerebellar ataxia caused by Pembrolizumab for Non-small cell lung cancer
Objective: We reported a case that cerebellar ataxia and decreased accumulation of right cerebellum at SPECT appeared after immunotherapy using immune-checkpoint inhibitor “Pembrolizumab” for Non-small…Inpatient vs outpatient workup of patients with ataxia and suspected paraneoplastic cerebellar degeneration: Does work-up location matter?
Objective: To assess the outcomes of patients with ataxia evaluated for paraneoplastic syndrome primarily in an outpatient or inpatient setting. Background: Although paraneoplastic ataxias are…Hemichorea revealing a putaminal cavernous angioma
Objective: Reporting an exceptional case of progrssive hemichorea revealing a putaminal cavernous angioma Background: Hemichorea is a rare movement disorder (MD) (0.7% of all MD)…Generalised Polymyoclonus In a Patient With Central Nervous System Tuberculosis
Objective: Myoclonus associated with tuberculosis or following an infectious event is a transient event with an abrupt onset. It is a rare phenomenon and often…Quercetin Regulates Cadmium Induced Motor Dysfunction in Depletion of Dopamine and its Metabolites at Synapse
Objective: The present study has an attempt to understand cadmium induced alteration in dopamine and associated signaling that causes the motor alterations in rats and…Chlorogenic acid attenuates the MPTP induced apoptosis in Parkinson’s disease mouse model through pAkt signaling pathway
Objective: This study deals to investigate and explore the anti-apoptotic and molecular mechanisms of CGA in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonian mice model. Background: The debilitating…Defence Mechanism of Ego and Coping Strategy Style of the Patient with Parkinson’s Disease
Objective: To find out the prevalence of different defence mechanism and coping strategies in the patients with PD.To find out the relationship between using of…
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