Design and Baseline Characteristics of an Open-Label, Randomized, 26-Week Study Comparing Levodopa-Carbidopa Intestinal Gel to Optimized Medical Treatment on Non-Motor Symptoms in Patients with Advanced Parkinson’s Disease – INSIGHTS Study
Objective: To evaluate the effectiveness of levodopa-carbidopa intestinal gel, LCIG (known as carbidopa-levodopa enteral suspension in the US), on non-motor symptoms (NMS) compared with optimized…Efficacy and safety of zonisamide in patients with dementia with Lewy bodies with parkinsonism: pooled analysis of phase 2 and 3 trials
Objective: To characterize the efficacy and safety of zonisamide (ZNS) in patients with dementia with Lewy bodies (DLB) with parkinsonism, a pooled analysis of two…RimbotulinumtoxinB in the treatment of adult sialorrhea
Objective: To assess efficacy, safety and tolerability of repeat injections of rimabotulinumtoxinBfor the treatment of sialorrhea. Background: Sialorrhea (drooling) can cause significant morbidity in several neurological disorders,…Does Team-based Outpatient Palliative Care Improve Patient or Care Partner-Centered Outcomes in Parkinson’s Disease and Related Disorders?
Objective: To assess whether outpatient palliative care (PC) improves patient or caregiver-centered outcomes in Parkinson’s disease and related disorders (PDRD) compared to current standards of…Effect of Once-Daily Opicapone on the Pharmacokinetics of Repaglinide
Objective: To evaluate the effect of once-daily administration of opicapone 50 mg on the pharmacokinetics (PK) of repaglinide. Background: Opicapone, a highly selective catechol-O-methyltransferase (COMT)…Evaluation of swallowing function by video-fluorography in patients with parkinsonism
Objective: The purpose of the present study is to investigate characteristic patterns of swallowing problems in each clinical entity of parkinsonism including Parkinson’s disease (PD)…Polyneuropathy in patients with continuous levodopa/carbidopa intestinal gel (LCIG) infusion
Objective: To assess frequency of polyneuropathy in patients with LCIG and the usefulness of routine nerve conduction studies follow-up Background: Continuous levodopa infusion is an…Vortioxetine treatment of depression in Parkinson’s disease
Objective: To assess efficacy and safety of Vortioxetine in Parkinson’s Disease (PD) patients affected by depression and its effects on motor performance. Background: Depression is…A phase IIa trial studying the safety and tolerability of IRL752 in patients with Parkinson’s disease dementia
Objective: The primary objective was to investigate the safety and tolerability of IRL752 in PD patients with dementia in a randomized controlled trial. Secondary outcome…Preclinical efficacy of drugs identified by IBM-Watson for repurposing to treat L-DOPA-induced dyskinesia
Objective: To test the efficacy of 3 drugs predicted by IBM Watson for Drug Discovery (WDD) as having the potential to treat L-DOPA-induced dyskinesia (LID).…
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