Comparative analysis of cognitive function between unilaterally and bilaterally affected Parkinson’s disease
Objective: To compare the cognitive function between unilateral and bilateral PD to identify whether worse cognitive impairment underlies in the bilateral group who had greater…Increased neurofilament light chain plasma levels as a biological marker of mild cognitive impairment in Parkinson’s disease
Objective: To examine whether PD-MCI patients have increased plasma neurofilament light chain (NfL) levels compared to PD with normal cognition (PD-NC) and healthy controls (HC).…Clock Drawing Test does not Differentiate Alzheimer’s Disease from Parkinson’s Disease Dementia
Objective: Our focus was on comparing the performance of CDT and MMSE in Parkinson’s Disease Dementia (PDD) and Alzheimer’s Disease (AD) patients. Background: The mini…Impulsive Control Behaviours in Patients with GBA, PARK2 and without Mutations in Genes Associated to Parkinson’s Disease
Objective: Aim of the study was to assess prevalence and severity of ICBs in PD patients with GBA mutations. Background: Parkinson disease (PD) is a…Contribution of coding/noncoding variants in NUS1 to late-onset sporadic Parkinson’s disease
Objective: Here, we designed a case-control study to analyze WGS variants in NUS1 coding regions and NUS1 related non-coding regions to investigate the relative contribution…Early predictors of Parkinson’s disease and prognosis in relatives
Objective: To study early clinical and biochemical markers of Parkinson's disease (PD) in relatives of Uzbek nationality. Background: Parkinson's disease is a neurodegenerative hereditary disease…DJ1 and α-Synuclein as CSF biomarkers and gene polymorphisms: association with clinical parameters in Parkinson’s disease
Objective: To analyze the CSF α-Synuclein and DJ1 Biomarkers correlating with SNCA and DJ1 gene polymorphisms and clinical parameters in PD. Background: Currently there is…Multiplex biomarker discovery for diagnostic and progression markers for Parkinson’s disease with the proximity extension assay technology on inflammation-related analytes
Objective: To identify diagnostic and progression biomarkers in the longitudinal DeNoPa cohort of (at enrolment) de novo Parkinson’s disease (PD) and healthy controls (HC) using…L-DOPA treatment in N2a cells stimulates neuromelanin biosynthesis: Using a novel in vitro model to examine the effect of iron and light on neuromelanin production
Objective: Naturally-occuring quantities of in vivo neuromelanin (NM) are low, and the collection of NM from tissue involves laborious extraction and isolation. Thus, in vitro…The feasibility of detailed phenotyping of muscle mitochondrial respiratory chain function and content in Parkinson’s disease
Objective: We aimed to determine: 1) the feasibility of obtaining and characterising skeletal muscle; and 2) if muscle mitochondrial respiratory chain (MRC) function and content…
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