Impact of ALXN1840 on the neurological symptoms of Wilson disease: secondary outcomes of a phase 2, open-label, single-arm study
Objective: To evaluate neurological efficacy outcomes of ALXN1840 treatment in adults with Wilson disease (WD) from a phase 2, open-label, single-arm study (NCT02273596). Background: WD…Does MDS-UPDRS provide greater sensitivity to mild disease than UPDRS for assessing motor severity in early Parkinson’s disease?
Objective: To test whether The Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III (Motor Examination) items provide increased sensitivity…New insight into REM-sleep atonia circuits underlying REM sleep behavior disorder in living humans
Objective: To investigate brainstem structural connectivity changes in REM sleep behavior disorder (RBD) patients using an in-vivo probabilistic brainstem nuclei atlas and 7 Tesla high…Retrospective review of MRI-guided focused ultrasound (MRgFUS) thalamotomy referrals: updated experience from a single movement disorder center
Objective: To evaluate referrals for MRI-guided focused ultrasound (MRgFUS) in terms of patient characteristics, reasons for referral, and decision outcomes. Background: Transcranial MRI-guided focused ultrasound…Personality dimensions could be predictive of quality-of-life outcome after deep brain stimulation of the sub-thalamic nucleus in Parkinson’s Disease
Objective: Our objective was to evaluate associations between personality dimensions and Quality of Life (QoL) amelioration after one year of Deep Brain Stimulation of the…Experience of DBS programming with directional leads
Objective: To report on the prevalence of and motivation for directional DBS programming in PD and ET over time. Background: Directional deep brain stimulation (d-DBS)…Predicting MDS-UPDRS Ratings for Deep Brain Stimulation Patients Using Wearable Sensor Data
Objective: To predict gait and speech scores of the (MDS)-Unified Parkinson’s Disease Rating Scale (UPDRS) for chronic subthalamic deep brain stimulation (STN-DBS) patients using wearable…Is there a place for virtual support groups for Parkinson’s disease in Africa? Lessons from the Covid-19 pandemic
Objective: Using a case study from Kenya to understand the potential role of virtual support groups for Parkinson’s disease (PD) in Africa. Background: The Covid-19…Multimodal Conversational AI for Remote Patient Monitoring and Analysis of Parkinson’s Disease
Objective: To present, analyze and evaluate a cloud-based audio-visual dialog agent and its associated automated speech, face and movement analytics for remote patient monitoring in…Development of quantitative tools for in-home clinical assessment of people with Parkinson’s disease
Objective: To develop telehealth digital data collection methods for evaluation of multi-modal function in people with Parkinson’s Disease (PwPD) and develop biomedical informatics tools for…
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