Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in enriched iPSC-derived human midbrain dopaminergic neurons
Objective: Develop and adapt a differentiation paradigm to produce enriched hiPSC-derived midbrain dopaminergic neurons (mDA), to resolve the temporal sequence of pathophysiological events in synucleinopathies.…Towards a Machine Learning Based Classification System for Hyperkinetic Movement Disorders: Generating a Neurophysiological Feature Set
Objective: Generating a set of significant neurophysiological features to build a machine learning based diagnostic system for hyperkinetic movement disorders. Background: Hyperkinetic movement disorders cause…Longitudinal study of clinical and neurophysiological features of essential tremor
Objective: This study investigates how motor and non-motor manifestations of essential tremor (ET) progress over time. Background: ET is a common and heterogeneous movement disorder…Clinical,imaging and genetic correlations in a Neuronal Brain Iron accumulation cohort from India
Objective: To correlate, clinical and magnetic resonance imaging (MRI) characteristics, of patients with neurodegeneration with brain iron accumulation (NBIA), with genetics and establish genotype-phenotype correlations…High preoperative gait variability is a prognostic predictor of gait and balance in Parkinson disease patients with deep brain stimulation
Objective: To elucidate the objective biomarker for long-term outcome of STN DBS in PD patients, we investigated the value of pre-operative quantitative gait parameters for…Resistance training in patients with Parkinson’s disease: a systematic review and meta-analysis
Objective: To analyze the effects of resistance training (RT) on motor- and non-motor outcomes in patients with Parkinson's disease (PD) compared to passive and physically…The results of DBS in patients with Parkinson’s disease for 10 years in Belarus
Objective: To study the efficiency and SE of DBS in PD patients in Republican Research and Clinical Center of Neurology and Neurosurgery in Belarus for…GDNF Gene Therapy for Parkinson’s Disease (PD): Preliminary Safety and Clinical Findings from a Phase Ib Study
Objective: Assess the safety and tolerability of intraputaminal AAV2-GDNF in mild to moderate PD Background: Glial cell line-derived neurotrophic factor (GDNF) is critical for dopaminergic…Nocturnal attacks of abnormal sleep behaviors and abnormal movements induced by insulin: A case report
Objective: To report a case of abnormal sleep behavior associated with hypoglycemia induced by insulin. Background: Hypoglycemia is a serious condition that can be manifested…Levodopa-carbidopa intestinal gel infusion and long-term tolerability in Parkinson’s: multicentre, international 13-year follow-up data
Objective: To evaluate the long-term range and nature of Levodopa-carbidopa intestinal gel (LCIG) infusion-related complications in people with Parkinson’s (PwP). Background: LCIG infusion is an…
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