CCL5 promotes Th17 migrating into SNpc by promoting Th17 proportion increase and LFA-1 expression
Objective: To explore the specific pathway by which CCL5 induces Th17 cells migrating into substantia nigra pars compacta (SNpc) to aggravate Parkinson's disease (PD). Background:…Inflammatory microglial and astroglial phenotype associated with pathological alpha-synuclein inclusions in the substantia nigra
Objective: To characterize neuroinflammatory gene expression in microglia and astrocytes associated with early alpha-synuclein (a-syn) inclusion formation. Background: Parkinson’s disease (PD) is characterized by alpha-synuclein…Impact of istradefylline on the adjustment of levodopa dose escalation in Parkinson’s disease: Results of the ISTRA ADJUST PD randomized, controlled study
Objective: To evaluate the effect of istradefylline (IST), an adenosine A2A receptor antagonist, on the adjustment of levodopa dose escalation in patients with Parkinson’s disease…Chronic Visceral Pain in Parkinson’s Disease and Link with White Matter Hyperintensities
Objective: To explore whether there is a link between chronic visceral pain and white matter hyperintensities (WMH) on brain magnetic resonance imaging (MRI) in People…Improving timely administration of PD meds in the hospital by using “custom” schedules
Objective: To determine if there are differences in timely administration of medications in hospitalized patients with Parkinson’s Disease (PD) when orders are placed for a…In-vivo measurement of tau depositions in anti-IgLON5 disease with 18F-PI2620-PET
Objective: The aim of the study was to examine the potential of the second-generation tau-PET tracer 18F-PI2620 to detect tau deposition in anti-IgLON5 disease. Background:…Impact of botulinum toxin treatment on gait in focal dystonia
Objective: To study the effects of botulinum neurotoxin (BTX) treatment on gait characteristics in patients with blepharospasm and cervical dystonia. Background: The impact of focal…Investigating the use of DAT-SPECT as an enrichment biomarker to determine eligibility for the phase 2 clinical trial PASADENA
Objective: Evaluate dopaminergic imaging DAT-SPECT as an enrichment strategy to avoid inclusion of participants with scans without evidence of dopaminergic deficit (SWEDD) in a Phase…Diagnosed and Drug-Treated Prevalence of Essential Tremor in Adult Patients: Retrospective Analyses of Two US Healthcare Claims Databases
Objective: Estimate the prevalence of diagnosed and drug-treated essential tremor (ET) in the adult population using 2 US healthcare claims databases. Background: ET is a…RE-EMERGENT TREMOR IN ESSENTIAL TREMOR; A PLUS SIGN FOR ET PLUS ?
Objective: This study aimed to investigate whether re-emergent tremor (RET) might also occur in essential tremor (ET) and if the cases with this additional sign…
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