Development of a quality-of-life (QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: Patient reported outcomes like “Health-Related Quality of Life” are one of the key outcome parameters of clinical studies. The aim of this project within…Non-myoclonic Subacute Sclerosing Pan Encephalitis in Adulthood
Objective: We report a case of subacute sclerosing panencephalitis (SSPE) presenting after a long latency without the usual clinical clues that aid in diagnosis. Background:…What, when and how should the information on iRBD and risk of Parkinson’s disease and related conditions be communicated?
Objective: To investigate what, when and how patients with iRBD would like to receive information regarding the potential future implications of having iRBD, once diagnosis…Electrophysiological correlates of neurological deficits in toxic-metabolic encephalopathy
Objective: We used transcranial magnetic stimulation (TMS) paradigms reflecting GABAA, GABAB, cholinergic and glutamatergic transmission at the motor cortex level, to investigate pathophysiology of different…Genetic determinants of early motor progression in Parkinson’s cohorts
Objective: To determine the genetic determinants of motor progression in Parkinson disease (PD) using genome-wide analysis correlated with the MDS-UPDRS Part III motor scale. Background:…Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson’s disease
Objective: To investigate the potential of transcranial static magnetic field stimulation (tSMS) as a non-pharmacological, non-invasive, home-based treatment to manage levodopa-induced dyskinesias (LIDs) in Parkinson’s…Social cognition and emotional processing in functional movement disorders
Objective: Our objective was to assess the social cognition (Theory of Mind) and emotional processing (alexithymia) in patients with functional movement disorders (FMD). Background: The…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…The role of intraoperative electrophysiological monitoring in implanting globus pallidus internus electrodes in patients with dystonia
Objective: The first aim was to compare the preplanned GPi electrode neuroradiological trajectory with the final trajectory selected after electrophysiological monitoring. The second aim was…Pooled safety analysis of incobotulinumtoxinA in the treatment of neurological disorders in adults
Objective: To examine the pooled incidence of treatment-emergent adverse events (TEAEs) and immunogenicity by indication in sponsored incobotulinumtoxinA (INCO) clinical trials in adults. Background: The…
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