SLP-2 modulated expression rescues mitochondrial function in alpha-synuclein neuropathology models
Objective: Validate the rescue potential of SLP-2 induction for α-synuclein (aSyn)-induced mitochondrial pathology and neurodegeneration in two complementary models: human induced pluripotent stem cell (hiPSC)-derived…Long-term effectiveness of adjuvant treatment with catechol-o-methyltransferase or monoamine oxidase B inhibitors compared with dopamine agonists in Parkinson’s disease uncontrolled by levodopa: final results of the PD MED LATER randomized clinical trial
Objective: PD MED LATER is a large, pragmatic trial aiming to determine which class of drug when added to levodopa provides the most effective control…Effects of a nurse-led Advance Care Planning and Care Coordination intervention in Parkinson’s Disease – patient and family caregiver perspectives from a multicentre European study
Objective: To investigate an Advance Care Planning (ACP) and care coordination intervention from the perspective of people with Parkinson's disease (PwPD) and their family caregivers…Transcriptional dysregulation in iPSC-derived neurons from patients with X-linked dystonia-parkinsonism
Objective: We pursue to identify dysregulated cellular pathways underlying X-linked dystonia-parkinsonism (XDP) by transcriptome profiling of induced pluripotent stem cell (iPSC)-derived neuronal cultures from XDP…Microbiota and Gastrointestinal Manifestations of Parkinson’s Disease with Arabic Translation of Gastrointestinal Dysfunction Scale
Objective: To investigate the frequency of occurrence of gastrointestinal tract GIT symptoms and their relation to patients’ clinical characteristics in addition the characteristics of gut…Exploring brain mechanisms of identity attribution in presence hallucinations of Parkinsonian origin
Objective: Study cognitive, behavioral correlates of identity of presence hallucinations in Parkinson’s disease. Background: Presence hallucination (PH), the sensation that someone is nearby when no…Effect of variants in COMT and UGT1A genes on clinical response in patients with Parkinson’s disease treated with opicapone
Objective: To identify genetic variants associated with different clinical responses in patients with Parkinson’s disease(PD) treated with opicapone. Background: Opicapone is a catechol‐O‐methyltransferase(COMT) inhibitor used…Low Vision Occupational Therapy for Parkinson’s Disease – A Pilot Study at the University of Alabama at Birmingham
Objective: Assess usefulness of low vision occupational therapy (OT) in a small cohort of Parkinson’s disease (PD) patients. Background: PD patients report vision-related symptoms more…WATCH-PD: Longitudinal Digital Assessments in Early Parkinson’s Disease
Objective: To provide a longitudinal profile of early Parkinson’s disease (PD) progression using clinical and digital measures, and to evaluate the extent to which digital…Risk of hallucinations and amantadine treatment in levodopa-induced dyskinesia patients with Parkinson’s disease: a meta-analysis of randomized controlled trials
Objective: The present meta-analysis aims to find out association between risk of hallucinations and amantadine treatment in levodopa-induced dyskinesia (LID) patients with Parkinson’s disease (PD).…
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