Early cognitive decline in Parkinson’s disease is anticipated by enhanced frontal theta oscillations and minor hallucinations
Objective: Identify alterations associated with minor hallucinations (MH) and their role in cognitive decline in patients with Parkinson’s disease (PD) by merging electroencephalography (EEG) with…Identification of ZYIL1, a novel NLR family pyrin domain containing 3 protein inhibitor: a potential disease modifier in Parkinson’s disorder
Objective: Identification and evaluation of the potential of a novel NLR family pyrin domain containing 3 (NLRP3) inflammasome inhibitor (ZYIL1) as a Parkinson’s disease (PD)…Heart-rate variability as a new marker for freezing predisposition in Parkinson’s disease
Objective: We aim to investigate for the first time whether it is possible to detect a predisposition for upcoming Freezing of Gait (FoG) events from…Reliability and validity of automatedly generated vowel space metrics as biomarkers of articulatory impairment severity and progression in early Parkinson’s Disease
Objective: To evaluate the reliability and validity of automatedly generated vowel space metrics from remotely collected smartphone speech samples as biomarkers of articulatory impairment severity…Population-Scale Long-Read Sequencing to Catalog Structural Variants in Parkinson’s Disease
Objective: We aimed to generate a population scale long-read sequencing dataset to begin to catalog structural variants in Parkinson’s disease (PD) to identify potential new variants…Impact of orthostatic hypotension with sleep disturbance on cognition
Objective: To define features of cognitive decline in a group of patients with orthostatic hypotension combined with sleep disorders. Background: recent data suggest that orthostatic…Montelukast as disease modifying treatment for Parkinson’s disease: a pilot study.
Objective: To assess safety and tolerability of high dose Montelukast as a possible disease modifying treatment for Parkinson’s disease. Background: Emerging evidence suggests that the…Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…Freezing of gait in Parkinson’s disease with glucocerebrosidase mutations: prevalence, clinical correlates and effect on quality of life
Objective: Mutations in glucocerebrosidase (GBA) can change the phenotype of Parkinson’s disease (PD). This study aimed to explore the clinical characteristics of freezing of gait…The role of the glymphatic system on the severity and distribution of alpha-synuclein pathology in alpha-synuclein fibril induced rat model of Parkinson’s disease
Objective: The aim of this study is to investigate the contribution of the glymphatic system to the pathophysiology of Parkinson's disease (PD). Background: Neurotoxicity of…
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