How do people with Parkinson’s disease experience self-optimization of treatment using digitally supported symptom monitoring?
Objective: The aim of this study was to investigate how people with Parkinson´s disease experience an intervention of optimizing their own medical treatment through digitally…Outcomes of patients treated with staged bilateral MRgHIFU thalamotomy using four-tract tractography targeting for medically refractory Essential Tremor
Objective: The goal of this study was to study the outcomes of 10 patients with medically refractory Essential Tremor (ET) treated with staged bilateral MR-guided…Influence of Cognitive Function on Obstacle-Crossing Performance in People with Parkinson’s Disease: A Cross-Sectional Study
Objective: This study investigated the influence of cognitive function on obstacle crossing performance in people with Parkinson's disease (PD). Background: Obstacle-crossing is a complex motor…Blood derived α-synuclein seeding in the course of Parkinson’s Disease
Objective: To identify seeding capacities of soluble α-synuclein (α-syn) conformers derived from neuronal extracellular vesicles (NEs) from Parkinson´s disease (PD) patients with different disease durations…Rasagiline in Chinese patients with early-stage parkinson’s disease: a randomized, double-blind, placebo-controlled, delayed-start trial
Objective: Objective: This randomized, double-blind, placebo-controlled, delayed-start trial aimed to investigate the efficacy in symptom improvement and disease-modifying effect of rasagiline for Chinese patients with…Cholinergic topography and clinical profile of early Parkinson’s patients with GBA mutations
Objective: To explore the regional cholinergic innervation and clinical profile of early Parkinson’s disease (PD) patients carrying GBA mutations (GBA-PD). Background: The most common genetic…In vitro α–synuclein aggregation and propagation model
Objective: Developing an in vitro α–synuclein (α-s) aggregation and propagation model of human cortical networks for functionality studies. Background: Studying α–s pathology and its effects…Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson’s disease: A Systematic Review and Network Meta-Analysis
Objective: We performed meta-analysis to determine the diagnostic and differential diagnostic value of α-syn SAAs for PD, and to investigate the optimal specimens. Background: Alpha-synuclein…Diagnosis of Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy with 7T-MRI substantia nigra imaging
Objective: To detect the signal change of nigrosome-1 in 7T-MRI and its diagnostic and differential diagnostic efficacy as the imaging biomarker of PD, MSA-P, MSA-C…The spatial and spectral organization of thalamo-cortical connectivity in patients with essential tremor
Objective: To identify cortical areas coupled to the ventral intermediate nucleus of the thalamus (VIM) in patients with essential tremor (ET). Background: ET is a…
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