Characterisation of OFF-Time in Levodopa-Treated Parkinson’s Patients: A Post-hoc Analysis of an Exploratory Trial
Objective: This analysis aims to study the evolution of OFF and ON patterns during a 12-hour daily period in patients with Parkinson’s disease (PD) and…Differential Rab10 & Rab8A phosphorylation by LRRK2 variants G2019S & I1371V manifests differences in membrane fluidity & pathogenicity.
Objective: To evaluate the difference in substrate (Rab8A & Rab10) phosphorylation by LRRK2 variants G2019S & I1371V on membrane fluidity & pathogenicity. Background: LRRK2 is…PSP-like phenotype triggered by STN DBS in PD: a case report
Objective: We report on a patient with Parkinson’s disease (PD) who developed reversible Progressive Supranuclear Palsy (PSP) like phenotype after bilateral subthalamic nuclear (STN) deep…Elevated plasma CREG1 levels are linked to a lower risk of Parkinson’s disease
Objective: The purpose of this study is to assess the causal associations between plasma cellular repressor of E1A-stimulated genes 1 (CREG1) levels and the risk…Role of bilateral pallidotomy in status dystonicus
Objective: The purpose of this study is to retrospectively review the results of bilateral pallidotomy in patients presenting with status dystonicus. Background: Dystonias, third commonest…Frequency of Parkinson disease following COVID-19 infection: a two-year retrospective cohort study
Objective: We aimed to utilize a large healthcare research network to determine the risk of developing Parkinson disease following COVID-19 infection compared individuals without COVID-19…Home-based titration with Duodenal infusion of Levodopa in People with Parkinson’s disease: an observational feasibility study
Objective: Primary objectives were to assess the feasibility and safety of LCIG home titration with use of telemedicine-assisted (TM) technology, and patient/caregivers satisfaction. Secondly, to…Network localization of limb ataxia
Objective: To identify the neural substrates of limb ataxia caused by stroke lesions. Background: Ataxia is a neurological sign defined by incoordination of voluntary movements.…Mesencephalic neuroglial cyst can produce clinical manifestations and a metabolic [18F] FDG PET pattern mimicking a Progressive Supranuclear Palsy Syndrome
Objective: To describe the clinical manifestations and structural and functional neuroimaging findings in a patient with a left mesencephalic neuroglial cyst, resembling a PSP. Background:…Motor function in Parkinson´s disease during 16h treatment with intravenously (DIZ101), subcutaneously (DIZ102), or intestinally (LCIG) infused levodopa
Objective: To compare the effect of intravenous (DIZ101) and subcutaneous (DIZ102) continuous 16h infusion of a continuously buffered acidic levodopa/carbidopa solution with levodopa/carbidopa intestinal gel…
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