Longitudinal clinical and biomarker characteristics of non-manifest GBA1 N409S carriers: the PPMI cohort
Objective: To examine longitudinal change in clinical characteristics, dopamine transporter (DAT) imaging and biofluid biomarkers in GBA1 N409S non-manifesting carriers (NMCs) versus healthy controls (HCs)…Continuous estimation of Parkinson’s on-off states using wearable devices
Objective: Utilize passive, continuous data from mobile and wearable devices to estimate on-off states in Parkinson’s patients. Background: The Hauser motor diary is often used…Wilson disease: a single-center study from Tunisia
Objective: We aimed to describe different clinical and radiological presentations of WD and insist on the necessity of early diagnosis to ensure therapeutic efficiency. Background:…MR-guided focused ultrasound pallidothalamic tractotomy in non-tremor dominant (akinetic-rigid) Parkinson’s disease treatment
Objective: The study aims to show that unilateral MR-guided focused ultrasound (MRgFUS) treatment akinetic-rigid Parkinson's disease (PD) can be safe and effective. Background: Parkinson's disease…Human cerebellum contributes to the motor frequency coding for essential tremor and volitional rhythmic movements
Objective: Tremor and volitional rhythmic movement are frequency-specific motions. However, it remains unclear which area of the central nervous system can process frequency information. This…Stop signal reaction time: A promising Diagnostic marker for Functional Cervical Dystonia
Objective: In the current study we explored the clinical utility of Stop Signal Reaction Time (SSRT) as a diagnostic marker for functional cervical dystonia (FCD).…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Habenula Volume in Mood Disorders in Parkinson’s Disease
Objective: To assess whether dysregulation of habenula (Hb) contributes to mood disorders in Parkinson’s disease (PD). Background: PD is often accompanied by mood disorders, such…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Development of a health-related quality-of-life (HR-QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: The aim of this project is to develop and validate a health-related quality-of-life (HR-QoL) questionnaire, in a patient and a caregiver version, specific for…
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