Stop signal reaction time: A promising Diagnostic marker for Functional Cervical Dystonia
Objective: In the current study we explored the clinical utility of Stop Signal Reaction Time (SSRT) as a diagnostic marker for functional cervical dystonia (FCD).…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Habenula Volume in Mood Disorders in Parkinson’s Disease
Objective: To assess whether dysregulation of habenula (Hb) contributes to mood disorders in Parkinson’s disease (PD). Background: PD is often accompanied by mood disorders, such…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Development of a health-related quality-of-life (HR-QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: The aim of this project is to develop and validate a health-related quality-of-life (HR-QoL) questionnaire, in a patient and a caregiver version, specific for…15-year effects of initiating treatment for Parkinson’s disease with dopamine agonists or monoamine oxidase B inhibitors compared with levodopa: final results of PD MED early disease randomisation
Objective: PD MED EARLY is a large, pragmatic trial aiming to determine which class of drug as initial treatment provides the most effective long-term control…The effect of lumboperitoneal shunt surgery on patients with iNPH plus Parkinson’s disease
Objective: To investigate the effect of lumboperitoneal shunt surgery on patients with iNPH comorbid with Parkinson’s disease Background: Comorbid Parkinson’s disease (PD) in idiopathic normal…Differential Spatiotemporal Gait Effects with Frequency and Dopaminergic Modulation in STN-DBS
Objective: The purpose of this study is to determine whether low frequency (LFS; 60Hz) STN-DBS elicits a differential response to high frequency (HFS;180hz) in spatiotemporal…Network attack tolerance: A resilience proxy for Parkinson’s disease?
Objective: To investigate if individual capacity in network attack tolerance moderates the relationship between striatal dopamine loss and symptom severity in PD. Background: It was…Eye tracking paradigm to identify disease-specific behavioral biomarkers in neurodegeneration
Objective: Rapid-eye movement (REM) sleep behavior disorder (RBD) has been identified as the most specific and common prodromal stages of α-synucleinopathies (αSYN) such as Parkinson's…
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