Evaluation of Neurotransmitter and Co-transmitter Expression in the Aging Human Locus Coeruleus: Relevance to Neurodegenerative Disorders.
Objective: To analyze the age-associated changes in the neurotransmitter/co-transmitter expression and morphometric profiles of human locus coeruleus (LC) neurons using autopsied human tissues. Background: LC…The Pro-LBD Study Investigating Early Detection, Prognosis, and Biomarkers of Prodromal Lewy Body Diseases
Objective: The Pro-LBD cohort study is a prospective, long-term, clinic-biological cohort study of participants who are stratified by their risk of developing a Lewy body…Hyposmia is Associated with Positive CSF α-Synuclein Seeding in Normal Pressure Hydrocephalus
Objective: To detect α-synuclein (αSyn) pathology and associated clinical characteristics in patients with idiopathic normal pressure hydrocephalus (iNPH) through cerebrospinal fluid (CSF) αSyn seed amplification…Adult Onset Spastic Paraplegia in TUBB4A Leukodystrophy
Objective: Introduction: Leukodystrophies are primarily known as childhood diseases, but recent advances in genetic testing and brain imaging have led to an increase in reports…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…Optical Coherence Tomography Findings in Multiple System Atrophy: Insights into Disease Subtypes, Clinical Correlations, and Dopaminergic Degeneration
Objective: This study aimed to evaluate optical coherence tomography (OCT) findings in multiple system atrophy (MSA) patients, with a focus on disease subtypes, clinical correlations,…Rapid Cognitive Deterioration and Related Factors in Progressive Supranuclear Palsy: a One-Year Follow-up Study
Objective: Based on a relatively large cohort, we aimed to show the switch of cognitive status in patients with progressive supranuclear palsy (PSP) after one-year follow-up…Cholinergic denervation is more severe in patients with Parkinson disease compared to Progressive Supranuclear Palsy-Parkinsonism subtype: A [18F]-FEOBV PET study
Objective: : To investigate cholinergic brain regional differences between Progressive supranuclear palsy with parkinsonism (PSP-P) and Parkinson's disease (PD), using the highly selective radiotracer for…Validation of Inertial Monitoring Units for Gait Assessment in Progressive Supranuclear Palsy
Objective: To evaluate the validity and precision of using inertial measurement units (IMU) for measurement of kinematics and spatial-temporal features of gait in progressive supranuclear…Salivary and Plasma Heme Oxygenase-1 Concentration as a New Potential Biomarker in Parkinson Disease
Objective: The objective was to assess the utility of plasma and salivary heme oxygenase-1 (HO-1) concentration as a new potential biomarker for the diagnosis of…
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