Untargeted Serum Metabolomics Identifies Glycine-Serine Metabolism Disruption as Biochemical Bignature in Parkinson’s Disease
Objective: We attempted to identify a metabolomic signature distinctive of Parkinson’s disease (PD) through an untargeted metabolomics approach. Background: Using an high-performance liquid chromatography targeted…A Machine Learning Approach for Early Identification of Prodromal Parkinson’s Disease
Objective: The aim of this project is to analyze available data of voice, Tappy keystroke, spiral drawings, and gait sample data involving PD patients and…Sub-insular enlarged perivascular spaces are associated with gait symptom severity and tap response in normal pressure hydrocephalus
Objective: We aimed to present two novel neuroimaging biomarkers based on enlarged perivascular spaces (ePVS) of the sub-insular territory: the Hedgehog and Hedgehog-Halo (H-H) sign…The Impact of Drug Interactions on the results of DAT-SPECT Imaging in a Specialty Movement Disorders Practice: A Retrospective Analysis of Outcomes
Objective: This study was a retrospective chart review of patients who underwent DAT-SPECT imaging for parkinsonism while on drugs listed as potentially interacting with the…Use of Machine Learning for Identification of Parkinson’s Disease and Mild Cognitive Impairment through Neuroimaging and Biofluid Biomarkers: A Study from the PPMI Cohort
Objective: Since current diagnostic tests for Parkinson’s Disease (PD) and mild cognitive impairment (MCI) focus on individual biomarkers, misdiagnoses can be frequent. This research aims…Cerebrovascular Reactivity and Glymphatic Clearance in Parkinson’s disease
Objective: To evaluate whether altered cerebrovascular reactivity contributes to reduced glymphatic clearance in Parkinson’s disease (PD). Background: Cerebrovascular activity is a major factor driving cerebrospinal…Ultrasonography Markers in Prodromal Parkinson’s Disease
Objective: This study aims to investigate ultrasonography markers as a potential imaging marker in prodromal Parkinson's disease, with the goal of identifying individuals at higher…Refining and Understanding Causal Relationships between Brain Imaging-Derived Phenotypes and Parkinson’s Disease: a Bidirectional Mendelian Randomization Study and Clinical Validation
Objective: Utilizing bidirectional two-sample Mendelian randomization, we explored the causal associations between imaging-derived phenotypes (IDPs) and Parkinson's Disease (PD), along with its manifestations. Background: Observational…Assessment of Visual Field in Patients with Moderate-to-Severe Parkinson’s Disease
Objective: Utilization of visual field testing and diffusion tensor imaging (DTI) to assess visual field deficits in patients with moderate-to-severe Parkinson’s Disease (PD) and identify…One-Year Outcomes of Multitarget Thalamic and Pallidal Deep Brain Stimulation in Unilateral Dystonia
Objective: This study presents the one-year outcomes of two patients who underwent unilateral deep brain stimulation (DBS) targeting the thalamic nuclei ventralis intermedius and ventralis…
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