Safety Profile of Opicapone in Elderly and Very Elderly Population
Objective: This study aimed to characterize the safety profile of opicapone (OPC) in the elderly and compare post-marketing safety between (A) very elderly patients (≥…Three-Year Single-Center Experience with Levodopa–Entacapone–Carbidopa Intestinal Gel in Advanced Parkinson’s Disease
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in advanced Parkinson’s Disease (APD). Background: LECIG infusion has been available in Romania since 2021.…Treatment Stability Across Different ADD-ON Therapies in Fluctuating Parkinson’s Disease
Objective: This study investigates the efficacy and tolerability of selegiline (SL), rasagiline (RS), safinamide (SF), and opicapone (OP) in fluctuating PD patients, focusing on treatment…Effect of COVID-19 Pandemic on Utilization of Parkinson’s Medications in Saudi Arabia: A Repeated Cross-Sectional Study
Objective: This study aims to examine the effects of the pandemic on the patterns of medication usage for Parkinson’s Disease (PD) in Saudi Arabia. Background:…Mapping aggregate monopolar sensing data of beta power local field potentials onto a common subthalamic nucleus in Parkinson’s disease patients
Objective: Compare local field potential (LFP) magnitude and anatomical location measured from a chronically implanted deep brain stimulation (DBS) lead within the subthalamic nucleus (STN)…Sleep-wake Alterations are Associated with a Decreased DTI-ALPS, a Marker of Perivascular Glymphatic Functioning, in Patients with Isolated REM Sleep Behavior Disorder
Objective: We aimed to explore circadian disruption in iRBD and its association with the Diffusion Tensor Imaging- ALong the Perivascular Space (DTI-ALPS) index, a proxy…Quantitative Measures of Cutaneous Phosphorylated Alpha-Synuclein: Powering a Disease Modification Clinical Trial In Parkinson’s Disease
Objective: To use a novel quantitative assessment of cutaneous P-SYN in a pilot study of patients with Parkinson’s disease (PD) and healthy volunteers (HVs) to…Relationship Between Motor Subtypes and Central and Peripheral Neurodegeneration in Early Parkinson’s Disease: A Study Using DAT SPECT and SUDOSCAN
Objective: To investigate the relationship between Parkinson’s disease (PD) motor subtypes and neurodegeneration in both the central and peripheral nervous systems using dopamine transporter single-photon emission…Tracking cortical and peripheral beta bursts in Parkinson’s disease during DBS modulation
Objective: We examined the relationship between cortical and peripheral beta bursts during symptom fluctuations in Parkinson’s disease (PD), and their response to deep brain stimulation…Plasma neurofilament light chain in early Parkinson’ s disease predicts motor complications: A Prospective Cohort Study
Objective: The current study aimed to identify risk plasma biomarkers in early-stage PD for future motor complications through a longitudinal Chinese PD cohort, which ultimately…
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