Engage- Qatar PD: The development of an online self-management intervention to promote engagement in physical activity for people with PD in Qatar
Objective: To develop the Engage-Qatar PD self-management intervention with cultural-adaptations for people with PD in Qatar. Background: Many people with PD engage in insufficient exercise…Frequency and outcome of PEG tube implantations in hospitalized Parkinson’s disease patients
Objective: We aimed to investigate the frequency and outcome of percutaneous endoscopic gastrostomy (PEG) tube implantation in patients with Parkinson’s disease (PD) during United States…Immediate Impact of Whole-Body Vibration on Backward Walking in Individuals with Parkinson disease
Objective: Determine the immediate impact of performing partial squats using whole-body vibration (WBV) versus level surface on backward walking velocity in People with Parkinson Disease.…Changes in Motor States Throughout the Waking Day With Tavapadon in People With Parkinson’s Disease
Objective: To evaluate motor states throughout the waking day when adding tavapadon to oral carbidopa/levodopa in adults with Parkinson’s disease experiencing motor fluctuations. Background: Long-term…Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of Vent-02, a Novel CNS-Penetrant NLRP3 Inhibitor for the Treatment of Parkinson’s Disease
Objective: The objectives of this first-in-human study were to assess the safety, tolerability, pharmacokinetics (PK), food-effect and pharmacodynamics of VENT-02 in healthy volunteers Background: Vent-02…Identifying subjects at high risk for prodromal Parkinson’s Disease using dopamine transporter imaging deficit in a step-wise recruitment strategy: Data of Healthy Brain Ageing (HeBA)
Objective: To optimize screening for subjects with dopamine transporter (DaT) imaging deficit being at high risk for prodromal Parkinson's disease (PD). Background: Efficient screening methods…Randomized Trial comparing Directional DBS with Ring-mode DBS in PD
Objective: To evaluate whether directional DBS is more effective in reducing PD motor symptoms and causes fewer stimulation-induced adverse effects (AE) than ring-mode DBS. Background:…A Phase 1b Study to Investigate Safety and Tolerability of Repeated Subcutaneous Doses of HER-096 in Subjects with Parkinson’s Disease
Objective: To investigate safety and tolerability of repeated subcutaneous (s.c.) doses of HER-096 in subjects with Parkinson’s disease. Background: HER-096 is a retro-inverso isomerized peptide…Quercetin Reduces mtDNA Release in PRKN-Deficient and Oxidatively Stressed SH-SY5Y Cells
Objective: This study investigates the role of Parkin deficiency in mitochondrial dysfunction and its contribution to mitochondrial DNA (mtDNA) release in Parkinson’s disease (PD). We…Advancements in Microbiome Research: Total Microbial Load, Differential Absolute Abundance, and Correlations with Immune Transcriptomics
Objective: Quantify total microbial load in the gut microbiome of people with Parkinson’s disease (PD) and compare the absolute abundance of bacterial taxa between PD…
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