Continuous, Subcutaneous Apomorphine Infusion (CSAI) for PD: Development of a Phase IV routine practice study to capture the patient, care partner, and healthcare professional experience in the United States
Objective: To develop a Phase IV study that can be used to inform best practice when considering continuous, subcutaneous apomorphine infusion (CSAI) as a treatment…Effect of Exenatide on disease progression in early Parkinson’s disease–a randomized, placebo controlled, single-center trial in Sweden
Objective: To identify biological mechanisms that mediate Exenatide's effect in the brain of patients with early Parkinson’s disease(PD). Background: Tracking PD progression remains a major challenge due to…Increased “Off” Time Is Associated With Poorer Clinical and Humanistic Outcomes in Patients With Advancing Parkinson’s Disease: Results From the PROSPECT Observational Study
Objective: To evaluate the association of increased “Off” time with clinical and humanistic outcomes in people with advanced Parkinson’s disease (PwP) inadequately managed by oral…Results from the PRIME-UK Randomised Controlled Trial
Objective: To evaluate whether PRIME-Parkinson care increases the ability of people with parkinsonism (PwP) to achieve their personal goals, has a positive impact on health…Multipronged, Community-Engaged Approach to Recruiting Lewy Body Dementia Family Caregivers for a National Trial
Objective: Describe a three-tiered initiative to recruit Lewy Body Dementia (LBD) family caregivers into a national randomized controlled trial (PERSEVERE, NCT06389032). Background: LBD is often…Trans-Spinal Theta Burst Magnetic Stimulation Enhances Treadmill Training Effects on Gait in Parkinson’s Disease
Objective: To investigate whether intermittent Theta Burst Trans Spinal Magnetic Stimulation(iTB–TsMS) enhance treadmill training benefit on gait function, freezing of gait(FoG), other motor symptoms and…GBA Mutations Alter Subthalamic and Nigral Neural Activity in Parkinson’s Disease
Objective: To investigate the neurophysiological basis of Parkinson’s disease (PD) in patients with glucocerebrosidase (GBA) mutations. Background: Alterations in subthalamic neural activity are associated with…Evaluation of Neuroprotective Effect of Terminalia macroptera on Rotenone Induced Parkinson’s Disease in Mice
Objective: This study investigates the neuroprotective effects of an aqueous extract of Terminalia macroptera (AETM) in a rotenone-induced Parkinsonism mouse model. Background: Parkinson’s disease (PD)…Treatment Of Advanced Parkinson’s With Levodopa–Entacapone–Carbidopa Intestinal Gel – Impact On Dyskinesia
Objective: To evaluate the effect of long-term treatment with levodopa–entacapone–carbidopa intestinal gel (LECIG) infusion on daily time with dyskinesia in people with advanced Parkinson’s disease…Opicapone for OFF Motor Fluctuations in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Trials
Objective: To evaluate the efficacy of opicapone 50 mg in reducing OFF time and improving motor function in Parkinson’s disease (PD) patients with motor fluctuations.…
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