Automating the assessment of motor symptoms of Parkinson’s: exploring the scope of assessment possible in a video-based approach.
Objective: To explore the scope of the PRIMS assessment in People with Parkinson’s (PwP), including symptom severity rating, assessment time, individual assessment item completion and…Depression and Social Engagement in Community-Dwelling Older Adults with Parkinsonism
Objective: To examine how depression and gait influence social engagement in parkinsonism. Background: Depression significantly affects quality of life in parkinsonism. Yet, the interplay of social…Studying the relationship between interoceptive awareness, caregiver burden, and disease perception in Parkinson’s Disease
Objective: Analyze the impact of interoceptive awareness deficits on caregiver burden in Parkinson's disease. Background: Interoceptive awareness (IA) is the ability to perceive and process…Enhancing Parkinson’s Nurse Care with AI-Driven Remote Symptom Monitoring
Objective: This project evaluates how AI-driven continuous monitoring and wearable sensors can support Parkinson’s disease (PD) nurses in optimizing medication schedules, assessing treatment efficacy, and…A Novel Therapeutic Targeting the tPA-NMDAr Interaction for Parkinson’s Disease
Objective: Glunomab, a monoclonal antibody designed to inhibit the interaction between tissue plasminogen activator (tPA) and the N-methyl-D-aspartate receptor (NMDAr), has demonstrated therapeutic potential across…Results From a Dose-Blinded, Phase II Extension Study Evaluating Long-Term Efficacy, Safety and Tolerability of Minzasolmin in Participants With Parkinson’s Disease
Objective: ORCHESTRA XT (PD0055; NCT05543252) was a Phase II, dose-blinded extension of the ORCHESTRA Phase II, proof-of-concept study (NCT04658186). ORCHESTRA XT assessed the pharmacodynamic effects of…Continuous, Subcutaneous Apomorphine Infusion (CSAI) for PD: Development of a Phase IV routine practice study to capture the patient, care partner, and healthcare professional experience in the United States
Objective: To develop a Phase IV study that can be used to inform best practice when considering continuous, subcutaneous apomorphine infusion (CSAI) as a treatment…Effect of Exenatide on disease progression in early Parkinson’s disease–a randomized, placebo controlled, single-center trial in Sweden
Objective: To identify biological mechanisms that mediate Exenatide's effect in the brain of patients with early Parkinson’s disease(PD). Background: Tracking PD progression remains a major challenge due to…Increased “Off” Time Is Associated With Poorer Clinical and Humanistic Outcomes in Patients With Advancing Parkinson’s Disease: Results From the PROSPECT Observational Study
Objective: To evaluate the association of increased “Off” time with clinical and humanistic outcomes in people with advanced Parkinson’s disease (PwP) inadequately managed by oral…Results from the PRIME-UK Randomised Controlled Trial
Objective: To evaluate whether PRIME-Parkinson care increases the ability of people with parkinsonism (PwP) to achieve their personal goals, has a positive impact on health…
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