Mass spectrometry-based screening for α-synuclein bioactive marine natural products
Objective: This study identifies marine-derived natural products with binding affinity and aggregation-inhibition activity against α-synuclein (α-syn) using a mass spectrometry (MS)-based screening approach. The objective…TMS-EEG Provides Objective Neurophysiological Measures of Motor Fluctuations in Parkinson’s Disease
Objective: To assess the correlates TMS evoked potentials (TEPs) measurements changes representing interhemispheric transmission to the change in motor symptoms in 'off' versus 'on' states.…Comparison of Microglial PET Imaging in Parkinson’s Disease, RBD, and Controls with a CSF1R and TSPO Ligand.
Objective: To compare regional binding patterns of microglial PET radioligands: [11C]DPA-713, a TSPO ligand, and [11C]CPPC1, a CSF1R ligand in people with Parkinson’s disease (PD).…Clinical Profile and 18F -Fluorodopa Positron Emission Tomography (18F -DOPA PET) Findings in a Movement Disorder Clinic Patient Cohort
Objective: This study aimed to evaluate the utility of 18F -DOPA PET in patients with diagnostic uncertainty at our movement disorder clinic in India. Background:…Impact of Aquaporin-4 polymorphisms on Glymphatic Function and Motor Symptoms in Parkinson’s Disease
Objective: This study aims to investigate whether single-nucleotide polymorphisms (SNPs) of the Aquaporin-4(AQP4) gene were related to abnormal protein accumulation (α-synuclein), glymphatic dysfunction (DTI-ALPS), and…Mining Metabolomics GWAS for Key Parkinson’s Disease Variants: A Bioinformatics Approach to Genetic-Metabolic Associations
Objective: To propose a novel approach to explore genetic-metabolic interactions in Parkinson’s disease (PD) by integrating the largest genome-wide association studies (GWASs) for PD and…Hispanic Recruitment to PD GENEration at Columbia University
Objective: To evaluate the effect of having a Hispanic, Spanish-speaking research coordinator on recruitment of Hispanic and Latinx people with Parkinson's disease to the PD…Longitudinal Analysis of Disease Progression in GBA-Associated Early-Onset Parkinson’s Disease
Objective: This study aims to investigate the longitudinal disease progression of early-onset Parkinson’s disease (EOPD) in carriers of GBA mutations compared to genetically undefined EOPD…VPS13C: a Modifier Gene causing Suboptimal Response to Levodopa in Early-Onset Parkinson’s Disease
Objective: To describe a retrospective clinical study of four cases carrying heterozygous pathogenic variants in the VPS13C gene with a clinical diagnosis of Early-Onset Parkinson’s…The Global Parkinson’s Genetics Program: Expanding the Diversity of Neurological Disorder Data: 2025 Update
Objective: To broaden the available data for Parkinson's Disease (PD) and related disorders by integrating genetic data from more than 115,000 participants worldwide through genotyping…
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