Split tablet dosing of Levodopa/Carbidopa/Entacapone 100mg/25mg/200mg in treating Chinese patients with early Parkinson’s disease: a single-center, prospective cohort study
Objective: To investigate split tablet dosing of Levodopa/Carbidopa/Entacapone (LCE) 100mg/25mg/200mg in treating Chinese patients with early Parkinson’s disease (PD). Background: LCE is a treatment option…Alterations of Plasma Membrane in Parkinson’s disease LRRK2 I1371V iPSC derived Astrocytes contribute to the vulnerability of the niche cells to Extracellular α-Synuclein
Objective: This study investigates the impact of LRRK2 I1371V mutation on astrocyte plasma membrane dynamics & its association with extracellular α-synuclein using astrocytes derived from…Exploring the ubiquitome in Parkinson’s Disease
Objective: To explore the role of ubiquitin signalling defects in Parkinson’s Disease. Background: Defects in ubiquitin signalling have been implicated in the pathogenesis of neurodegenerative…Impaired Speech Perception in Noise (SPiN), Hearing Loss, and Cholinergic Denervation in Parkinson’s Disease
Objective: This study will investigate the relationships among speech-perception-in-noise (SPiN), hearing acuity, and cholinergic system changes in patients with PD. Background: Recent studies highlight a…Effect of Aβ on α-synuclein propagation
Objective: To investigate how amyloid-beta (Aβ) pathology affects α-synuclein (α-syn) propagation. Background: Lewy bodies, the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies,…Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Objective: To investigate the significance of Lewy body pathology (LBP) in relation to midbrain molecular and cellular changes associated with Parkinson's disease (PD). Background: The…Hippocampal-striatal interaction and cognitive decline in Parkinson’s disease with mild cognitive impairment
Objective: We aimed to investigate the interaction between hippocampus and dopaminergic pathways in PD with mild cognitive impairment (PD-MCI). Background: Dysfunction of striatal dopaminergic neurotransmitter…Dual task elicited premotor and supplementary motor activity as sensitive markers of mild Parkinson’s disease: an fNIRS analysis
Objective: This study aimed to explore dual-task (DT)-related cortical hemodynamic response (CHR) differences across healthy older adults (HOA), mild Parkinson’s disease (PD), and moderate PD…Identifying Cut-off Values, Effects of AD Co-pathology, Sex Differences, and Temporal Changes of 123I-FP-CIT SPECT in Autopsy-proven LBD
Objective: We analyzed autopsy-proven Lewy body disease (LBD) and/or Alzheimer’s disease (AD) dementia patients with 123I-FP-CIT SPECT to investigate previously unclarified detailed aspects of 123I-FP-CIT…Association of Mitochondrial DNA Haplogroup and pS65-Ub Levels in Lewy Body Disease
Objective: To determine whether specific mitochondrial DNA (mtDNA) haplogroup(s) affect the level of p-S65-Ub as quantitative marker of mitochondrial damage in Lewy Body Disease. Background:…
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