GCase and Ganglioside GM1 Interaction in Parkinson’s Disease
Objective: The project aims to further understand the role of the ganglioside GM1 in the relationship between GBA1 mutations and higher α-synuclein levels. Background: Among…Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo
Objective: To investigate the specific effects of the core complement component C4 on α-synuclein aggregation and neuroinflammation during the pathogenesis of PD. Background: Synucleinopathies are…Longitudinal Brain Morphometric Trajectories Across Parkinson Disease Clinical Subtypes
Objective: To investigate longitudinal brain morphometric trajectories across Parkinson disease (PD) clinical subtypes Background: We developed a PD multi-domain classification based on motor and non-motor…Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations
Objective: Apply four differential equations to generate projections considering the effect of dopamine on Parkinson’s disease progression, leading to the development of an initial prototype…Prevalence and Clinical Characteristics of iNPH-Related Imaging Findings (DESH) in Parkinson’s Disease
Objective: To investigate the prevalence of idiopathic normal pressure hydrocephalus (iNPH)-related imaging findings (DESH) and their clinical characteristics in Parkinson’s disease (PD) patients. Background: PD…Semi-quantitative Evaluation of Midbrain Accumulation in 123I-FP-CIT SPECT in Parkinson’s disease and Parkinsonian Syndromes
Objective: To establish a method for evaluating midbrain accumulation of 123I-FP-CIT SPECT and assess its ability to differentiate between Parkinson’s disease (PD) and Parkinsonian syndromes…Prospective Tractography-Guided STN DBS Targeting with Optimized vmPFC Connectivity for Apathy in PD a Case Report
Objective: Prospective tractography-guided DBS targeting of the left STN-vmPFC and primary motor pathway to improve apathy alongside motor symptoms in PD. Background: While STN DBS…Uncovering the heterogeneity of spatiotemporal trajectories of neurodegeneration in Parkinson’s disease: an early-phase 18F-FP-CIT PET study
Objective: To define the subtypes of Parkinson’s disease (PD) based on the spatiotemporal progression patterns of cerebral hypoperfusion. Background: Early-phase 18F-FP-CIT PET images, which are…Using Multi-Generational High-Risk Pedigrees to Identify Candidate Parkinson’s Disease Predisposition Genes
Objective: To identify rare genetic variants associated with increased risk of Parkinson’s disease (PD) in multi-generational, high-risk pedigrees. Background: Our current knowledge of PD genetics…Does COMT Play a Role in Parkinson’s Disease Susceptibility Across Diverse Ancestral Populations?
Objective: To investigate the relationship between COMT genetic variants and PD risk across diverse ancestries. Background: The enzyme catechol-O-methyltransferase (COMT; OMIM:116790) plays a crucial role…
- « Previous Page
- 1
- …
- 19
- 20
- 21
- 22
- 23
- …
- 181
- Next Page »