Functional Segregation in Parkinson’s Disease
Objective: We assessed patterns of dopamine (DA) release and striatal activation induced by behavioural tasks involving corticostriatal loops in Parkinson’s disease (PD) and healthy control…Exploring the Association between Autonomic Responses and Dopaminergic Pathways in Early Parkinson’s Disease
Objective: To assess if cardiovascular dysautonomia, evaluated by autonomic function tests (AFTs), is related to dopaminergic nicgrostriatal loss and other non-motor symptoms in early Parkinson…Sex-specific genetic architecture of autosomal risk for Parkinson’s Disease: from the Global Parkinson’s Genetics Program
Objective: To investigate potential differences in autosomal risk factors between males and females with Parkinson’s Disease (PD). This analysis was performed within and across genetically…Prevalence and Local Ancestry of LRRK2 p.Q1111H in Latin American Cohort
Objective: To expand upon previous work assessing the prevalence of the LRRK2 p.Q1111H variant in Latin America and implement local ancestry analysis to assess ancestral…Genetics of African Americans – Louisiana, Parkinson’s Disease – (GoAAL-PD)
Objective: Study a cohort of African American patients with PD to understand the genetic underpinnings, phenotypes, barriers to care, and engagement preferences unique to this…Clinical Differences Among Parkinson’s Disease Patients Carrying GBA1 Variants in Colombia: Insights From LARGE-PD Consortium
Objective: To compare the clinical manifestations of GBA1 variants p.K198E, p.E326K, and p.N370S in Parkinson’s disease(PD) patients in Colombia. Background: GBA1 variants have been identified…Assessing Individual Risk Through Determination of Local Ancestry: Insights from the Global Parkinson’s Genetics Program
Objective: We're developing a scalable pipeline to infer local ancestry (LA) for individuals in the Global Parkinson's Genetics Program (GP2). This approach aims to enhance…Screening for GBA1 p.K198E PD-Risk Variant in Latin America
Objective: We aimed to assess the distribution of the GBA1 p.K198E variant, linked to Gaucher’s disease (GD) and increased Parkinson’s disease (PD) risk, across Latin…Delirium following deep brain stimulation: An 8 year single-centre study
Objective: To describe the outcomes of patients undergoing deep brain stimulation (DBS) surgery for movement disorders and neuropsychiatric indications and characterise delirium symptoms. Background: Deep…Beyond UPDRS: personalizing the assessment of different DBS modes
Objective: The added benefit from adaptive (aDBS) compared with conventional deep brain stimulation (cDBS) is largely heterogeneous, and the perceived benefit is subjective. In this…
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