Deep Brain Stimulation in Late-Stage Parkinson’s Disease: Insights from Clinical Practice
Objective: To compare Late-stage Parkinson's disease (LSPD) patients who completed at least one year of oral medical therapy alone after IPG depletion with those who…Rescue GPi DBS for Severe Dyskinesias and Dystonia in Long-Term STN DBS Parkinson’s Patients: A Case Series
Objective: Evaluate GPi DBS as a rescue therapy for refractory dyskinesias and dystonia in long-term STN DBS patients. Background: STN DBS effectively reduces medication dependency…Olfactory-Trigeminal Interactions in Parkinson’s Disease Compared to Other Olfactory Disorders
Objective: To investigate the interaction between the olfactory and trigeminal systems in Parkinson’s disease (PD) as opposed to other forms of olfactory dysfunction and controls…A Resting-State fMRI Study of Regional Homogeneity about Pain in Parkinson’s Disease
Objective: The purpose of our study is to explore the differences in ReHo patterns under acute and chronic pain conditions in Parkinson's disease (PD) patients, aiming to provide…Neural Correlates of Impaired Apathy Self-awareness in Parkinson’s Disease
Objective: To examine the presence of apathy self-awareness in PD patients using a dimensional approach Background: Apathy, or loss of motivation, is a common neuropsychiatric…The role of serotonergic mechanisms in the formation of levodopa-induced drug-induced dyskinesias in Parkinson’s disease
Objective: To study the quantitative content of serotonin and dopamine in the blood plasma of patients with Parkinson's disease and to conduct a clinical and…Alterations in gut microbiota composition in VPS35 associated PARK17 mouse model
Objective: This study explores whether host genetics such as specific VPS35 genetic variations linked to PD can shape the gut microbiome. Background: Heterozygous (D620N) mutation…Hemimasticatory Spasm: A Report of Two Cases
Objective: We present two HMS patients with distinct Doppler ultrasonography findings in the involved masseter muscle, however, both responded favorably to botulinum toxin A injections.…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…AI-Based Detection of Tremor and Dystonia Using Deep Learning Models: A Novel Approach
Objective: Primary Objective:To develop and evaluate a machine learning-based model for the accurate classification of tremor and dystonia using video data.Secondary Objectives:To address the shortage…
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