Exposure-Response Analysis of Glovadalen in the ATLANTIS Phase II Study: Trial Simulation Explains Dose-Response for OFF Time in Parkinson’s
Objective: This analysis characterized the exposure-response (E-R) relationship of glovadalen (UCB0022) in the ATLANTIS Phase-IIa proof-of-concept study, to understand the apparent lack of dose-response for…Astrocyte Derived Extracellular Vesicle miR 210 Expression in Exenatide Treated Patients with Parkinson’s Disease
Objective: To investigate miR‑210 expression in astrocyte‑derived extracellular vesicles (ADEVs) from individuals with PD treated with Exenatide versus placebo. Background: Hypoxic stress profoundly alters neuronal…MobilityAPP: A randomized-controlled trial evaluating gait-focused physiotherapy in Parkinson’s disease and atypical parkinsonian syndromes
Objective: Effect on gait and balance of gait-focused physiotherapy compared to standard-of-care physiotherapy in patients with MSA, PSP and PD. Background: Physiotherapy is a crucial element…Automated Speech Analysis for the Differentiation of Multiple System Atrophy from Parkinson’s Disease in an English-Speaking Cohort
Objective: The aim of this pilot study was to determine whether automatically extracted speech features, derived from targeted speech tasks, can differentiate Multiple System Atrophy…DBS withdrawal syndrome in Parkinson’s disease: Clinical features and outcomes of two new cases
Objective: To report two cases of deep brain stimulation (DBS) withdrawal syndrome in Parkinson’s disease (PD), including one without typical risk factors. Background: DBS withdrawal…NPC2 is an Allele-Specific Modifier of GBA1-Associated Parkinson’s Disease Risk
Objective: To identify rare variant modifiers of GBA1-associated Parkinson's disease (PD) penetrance among lysosomal storage disorder (LSD) genes. Background: GBA1 is the most common large-effect…The Challenges for Diagnosis of Movement Disorders in Ukraine
Objective: The purpose of our study was to identify the main problems faced by general neurologists (GN) when diagnosing movement disorders (MD) in Ukraine. Background:…REM Sleep Behaviour Disorder and early non-motor symptoms in Parkinson’s Disease
Objective: To investigate early non-motor symptoms between the RBD-positive and RBD-negative PD patients from the Early Parkinson’s Disease Longitudinal Singapore study (PALS) cohort. Background: REM…Longitudinal α-synuclein Seed Amplification Assay Analysis of PPMI Participants
Objective: To evaluate longitudinal consistency in the assessment of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) by α-synuclein seed amplification assay (synSAA). Background: synSAA…Can Prayer Beads Quantify Bradykinesia? An Ultra-Low-Cost Approach to Motor Assessment in Parkinson’s Disease
Objective: To explore the potential use of portable mechanical counters as a simple approach to quantifying finger movement activity in the evaluation of bradykinesia. Background:…
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