Pesticide Exposure and Smoking in Parkinson’s Disease in Kyrgyzstan: A Case–Control Study
Objective: To investigate environmental exposures associated with Parkinson’s disease (PD) in Kyrgyzstan, focusing on pesticide exposure and smoking, and to explore potential sex-stratified associations. Background:…Biofluid Markers in Parkinson’s Patients and Correlation with Cognitive Profile
Objective: The purpose of this study was to determine potential biofluid biomarkers for cognitive impairment in a cohort of Parkinson's disease (PD) patients. Here we…A Case of NUS1 Spectrum Disorder with Adult-Onset Psychosis
Objective: To report a novel case of NUS1 spectrum with childhood-onset abnormal movements and adult-onset psychiatric manifestations. Background: The NUS1 gene is associated with developmental…Body Weight Increases After DBS in Parkinson’s Disease but Not Essential Tremor
Objective: This retrospective longitudinal cohort study examined body weight trajectories surrounding unilateral and staged bilateral deep brain stimulation (DBS) across surgical targets in individuals with…ANK2 Mutations Associated with a Myoclonus-Dystonia Phenotype: Expanding the Neurological Spectrum of Ankyrin-B Dysfunction
Objective: To deeply characterize the clinical and genetic spectrum of ANK2-related hyperkinetic movement disorders and expand their recognized link to myoclonus-dystonia phenotype. Background: The ANK2…Monitoring Levodopa Responsiveness in Parkinson’s disease using wearable sensors: the digital levodopa challenge
Objective: To investigate acute and short-term motor responses to Levodopa in drug-naive PD patients using combined clinical assessment and wearable sensor-based gait analysis. Background: Levodopa…Prevalence and Treatment Patterns of Anxiety Symptoms in Parkinson’s Disease
Objective: To examine the prevalence of clinically significant anxiety symptoms, their overlap with depressive symptoms, and associated pharmacologic treatment patterns in Parkinson's disease (PD). Background:…Diagnostic Test Utilization and Timing in a Multidisciplinary Gastrointestinal Symptom Clinic: Insights from the Parkinson’s Research and Integrated Support Model (PRISM) Clinic
Objective: This study evaluates the diagnostic yield of an algorithm-based approach implemented in the Parkinson’s Research and Integrated Support Model (PRISM) clinic [1]. Background: Gastrointestinal…SCA-2 Presenting as Isolated Progressive Spastic Paraparesis
Objective: Describe an infrequently encountered phenotypical presentation of Spinocerebellar ataxia (SCA) Background: SCAs are a group of genetically diverse neurodegenerative disorders marked by high clinical heterogeneity. …Long-Term Open-Label Data on the GCase Modulator GT-02287 in People with Parkinson’s Disease
Objective: To evaluate the long-term safety, tolerability, and PK of the oral, brain-penetrant glucocerebrosidase (GCase) modulator GT-02287 in people with Parkinson’s disease. Background: Preclinical evidence…
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