Mechanistic study of PARP9-mediated mitochondrial transfer in regulating dopaminergic neuronal injury and neuroinflammation in Parkinson’s disease
Objective: To investigate PARP9 expression and localization in PD models, evaluate its effects on dopaminergic neuronal injury and microglial activation, and determine whether PARP9 regulates…The Global Parkinsons Genetics Program: Expanding the Diversity of Neurological Disorder Data – 2026 Update
Objective: To broaden the available data for Parkinson's Disease (PD) and related disorders by integrating genetic data from more than 140,000 participants worldwide through genotyping…Genomic Insights into Parkinson’s Disease: LARGE-PD and PD GENEration Collaboration in El Salvador
Objective: To characterize clinical and genetic features of Parkinson’s disease (PD) in El Salvador in the PD GENEration and LARGE-PD. Background: Central American populations remain…Exploring the Relationship Between Insomnia and Autonomic Dysfunction in Parkinson’s Disease: A 1 Year SCOPA-AUT Analysis
Objective: To evaluate the progression of autonomic dysfunction over one year in patients with Parkinson’s disease (PD) with and without comorbid insomnia. Background: Insomnia and…“Step-by-Step” in Movement Disorders: A Disease-Specific, Multi-Method Integrated Teaching Approach
Objective: To evaluate the effectiveness of a novel “Step-by-Step” teaching round model in improving neurology residents’ knowledge and clinical competency in movement disorders. Background: Movement…Phenotypic and Genotypic Spectrum of MAPT-associated Parkinsonism in a Multi-ethnic Malaysian Cohort
Objective: To describe the phenotypic continuum and genotypic spectrum of microtubule-associated protein tau (MAPT)-associated parkinsonism in a multi-ethnic Malaysian cohort. Background: Carriers of pathogenic MAPT…Urine-derived neuronal extracellular vesicle α-synuclein seed amplification assay for synucleinopathies: a non-invasive biomarker study
Objective: To investigate whether pathogenic α-synuclein can be detected using real-time quaking-induced conversion (RT-QuIC) in urine-derived neuronal extracellular vesicles (NEVs) as a fully non-invasive biomarker…Brain-Derived Neurotrophic Factor as a Biomarker of Depression in Parkinson’s Disease
Objective: To determine whether peripheral neurodegeneration-related biomarker levels differ between patients with Parkinson’s disease (PD) with and without depression and to identify biomarkers associated with…Clinical and Functional Outcomes of Antiviral and Immunomodulatory Therapies in Subacute Sclerosing Panencephalitis
Objective: To evaluate whether antiviral and immunomodulatory treatments meaningfully improve true functional status and disease stabilization, or if they merely prolong survival in a state…Botulinum toxin treatment patterns and outcomes in head and neck dystonia: experience from a tertiary, multidisciplinary clinical service
Objective: To evaluate outcomes following Botulinum toxin (BoNT) treatment for head and neck dystonia in a tertiary multidisciplinary clinic, characterise adverse effects and identify treatment…
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