Objective profiling of parkinsonian and essential tremor using EMG and accelerometry
Objective: To determine whether electrophysiological features derived from EMG and accelerometry can distinguish PD tremor from ET. Background: Clinical differentiation between tremor in Parkinson’s disease…Accelerated brain iron accumulation secondary to hypoxia in a patient with hereditary haemochromatosis with homozygous C282Y mutations.
Objective: To describe the case of a 60-year-old male with a diagnosis of Hereditary Haemochromatosis (HHE) with homozygous C282Y mutations presenting with progressive parkinsonism, cognitive…Reconfiguration of Structural-Functional Coupling Associated with Clinical Features and 5-Year Progression in Parkinson’s Disease: A Cross-sectional and Longitudinal Study
Objective: This study aimed to characterize Structural–functional coupling (SFC) reorganization in Parkinson’s disease (PD), examine its associations with motor and cognitive performance, and assess whether…A Therapeutic Approach to Writer’s Cramp-Type Focal Dystonia Using Botulinum Toxin: Experience of the Neurology/Movement Disorders Department of the Hospital do Servidor Público de São Paulo
Objective: To characterize the clinical and demographic profile of patients with writer’s cramp treated at the botulinum toxin outpatient clinic of the Instituto de Assistência…Expanding the Phenotypic Spectrum of PRRT2 Channelopathy: A Homozygous Mutation With Early Epilepsy, Autism And Dysmorphism In A Consanguineous Family
Objective: Case Report Background: A child born to third-degree consanguineous parents presented with seizures beginning at 2.5 months of age. Over time, the child developed…Towards intraoperative physiology-informed design of intermittent burst deep brain stimulation
Objective: We aim to monitor the deep brain stimulation (DBS) circuit engagement at single neuron resolution and want to leverage this insight for physiology-driven design…Global Momentum in Parkinson’s Disease Therapeutics: Ten-Year Trends in Mechanisms, Modalities, and Clinical Endpoints
Objective: To characterize current trends in Parkinson’s disease (PD) clinical development by analyzing global interventional trials from the past decade, focusing on trial phase distribution,…Wearable IMU-Based Gait Analysis Reveals Pharmacological Freezing-of-Gait Phenotypes in Parkinson Disease: A Longitudinal Two-Visit Study
Objective: TolongitudinallyevaluatewearableIMU-derived gaitparameters across two clinical visits andcharacterizepharmacological responsephenotypes inParkinsondiseasepatientswith freezingof gait (FOG). Background: FOG affects upto 80% of patientswith advanced PD and frequentlydemonstrates absent…Clinical Spectrum of Atypical Parkinsonian Disorders in Sri Lanka: Preliminary Results from a Global Parkinson’s Genetic Programme (GP2) Collaborative Study
Objective: To examine the clinical patterns, diagnostic types, and daily functional impact of atypical parkinsonian disorders (APD) within a Sri Lankan patient group Background: Atypical…The Syn-Q Study: Quantification of phosphorylated alpha-synuclein in patients with Parkinson’s disease and REM sleep behavior disorder
Objective: To define changes in cutaneous P-SYN quantitation over 18 months in patients with Parkinson’s disease (PD) and isolated REM sleep behavior disorder (iRBD).To define…
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