Sex-Specific Associations of APOE ε4 with Cognitive Decline in Parkinson’s Disease: Insights from the Critical Path Institute GEM-PD Initiative
Objective: We aim to advance precision medicine strategies for Parkinson’s disease (PD) through data-driven research led by the Critical Path for Parkinson’s (CPP) global public-private…A case of monotherapy with intracerebroventricular anaerobic dopamine allows complete control of Parkinson’s disease symptoms
Objective: To investigate the safety and efficacy of continuous circadian and personalized intracerebroventricular (i.c.v.) administration of anaerobic dopamine (A-dopamine) in Parkinson's disease patients refractory to…Parkinson’s Disease and Parkinsonism Family Center Psychoeducational Program for Patients and Caregivers
Objective: To provide structured psychoeducational and informational support, including disease education, coping and self-management strategies, and guidance on healthcare and social services for Parkinson’s disease…Digital Speech Biomarkers Reveal Speech Changes in Physiological Aging and Parkinson’s Disease
Objective: This study investigates speech characteristics associated with physiological and pathological aging, using Parkinson’s disease (PD) as a model, with the aim of identifying linguistic…A novel pro-drug overcomes short-half life and absorption challenges and increase brain penetration of dopamine as a potential therapy for Parkinson’s disease
Objective: We developed a new small molecule drug candidate that would increase the effectiveness of dopamine delivery to the brain. We also sought to mitigate…Clinical Drug-Drug Interaction Profile Of BIA 28-6156: Results From Three Independent Phase I Studies
Objective: Three independent, open-label, clinical drug-drug interaction (DDI) studies were conducted to characterise the clinical DDI profile of BIA 28-6156. Background: BIA 28-6156 (paricerat) is…Ataxia as the Primary Symptom of Leber Hereditary Optic Neuropathy: A Case Report of a Patient and Family Observation
Objective: To highlight the possibility of ataxia developing as the primary symptom of Leber hereditary optic neuropathy (LHON). Background: LHON is a mitochondrial disorder characterized…The Parkinson’s Impact Project: A Multimodal Longitudinal Study of Disease Development and Progression at the 23andMe Research Institute
Objective: Characterize the interactions between lifestyle, environmental, and genetic exposures on susceptibility to Parkinson’s disease (PD) and progression rates through a scalable remote web-based multimodal…The Effects of Bright Light Therapy on Improving Sleep Disorders in Parkinson’s Disease
Objective: To explore the effects of bright light therapy (BLT) on improving sleep disorders in Parkinson‘s disease (PD). Background: Sleep disorders are common clinical symptoms…Long-Term Effects of Repeated Home-Based tDCS on Language Production in Parkinson’s Disease
Objective: To investigate the long-term effects of repeated home-based transcranial direct current stimulation (tDCS) on language production in patients with Parkinson’s disease (PD). Background: Language…
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