Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…High Frequency of Pathogenic Variants in Neurodevelopmental Genes in Patients with Dystonia
Objective: To systematically investigate the occurrence of pathogenic variants in genes linked to neurodevelopmental disorders (NDD) in patients with dystonia. Background: Partially overlapping genetic causes…Robot-Assisted Transplantation of Hypoimmune iPSC-Derived Dopaminergic Progenitor Cells for PRKN-EOPD
Objective: This study aimed to evaluate the safety and preliminary efficacy of NCR201 transplantation in a PRKN-EOPD patient, providing a first proof-of-concept for this hypoimmune…A Specific Neuronal Subpopulation in Globus Pallidus External Segment Mediates the Pathogenesis of Dyskinesia in Parkinson’s Disease
Objective: To clarify the causality between neuronal activity in globus pallidus external segment (GPe) and levodopa-induced dyskinesia (LID), and further ascertain the specificity of this…Severity of Psychotic Symptoms Is Independently Associated with Caregiver Burden in Parkinson’s Disease: A Cross-Sectional Analysis
Objective: To evaluate the association between psychotic symptom severity and caregiver burden in patients with PD. Background: Psychotic symptoms are common in Parkinson’s disease (PD)…Multicenter Evaluation of Automated Structural MRI-based Diagnosis for Multiple System Atrophy
Objective: This study aims to evaluate whether automated classification based on individual voxel-based morphometry (VBM) adjusting covariates (iVAC) can achieve high diagnostic accuracy for MSA…Delayed Parkinsonism Following Japanese Encephalitis: A Case Report with Dopamine Transporter Imaging and L-dopa/DCI treatment
Objective: To report a case of Japanese encephalitis (JE) presenting with thalamic–midbrain lesions followed by delayed parkinsonism confirmed by dopamine transporter imaging. Background: JE is…Multi-ancestry analysis of POLG variants in Parkinson’s disease
Objective: To investigate the genetic spectrum and prevalence of POLG variants in PD across diverse ancestries. Background: Variants in the polymerase gamma (POLG) gene are…Accelerating the Implementation of Network-based Care for Parkinson’s Disease (ACTION-PD)
Objective: The aim of the study was to evaluate the implementation of network-based care for people living with Parkinson’s disease (PwPD). Background: ParkinsonNet is a…Comparative Effectiveness of Tavapadon Versus Real-world Oral Standard of Care Treatments in Parkinson’s Disease With Motor Fluctuations: an Indirect Comparison Analysis
Objective: To compare clinical-trial tavapadon with real-world oral standard of care (SoC) in patients with Parkinson’s disease (PD) experiencing motor fluctuations. Background: In the phase…
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