Thalamic Hub Dysregulation in FCMTE1: Multimodal MRI and Gene-Imaging Evidence
Objective: To characterize brain network abnormalities and gene-imaging associations in genetically confirmed FCMTE1 (SAMD12) patients using multimodal MRI. Background: Familial cortical myoclonic tremor with epilepsy…Efficacy of Deutetrabenazine in Patients with Tourette Syndrome: A Meta-Analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy of deutetrabenazine in patients with Tourette syndrome (TS). Background: Deutetrabenazine is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor. While…Wearable Sensors Identify Mobility Features Associated With Parkinson’s Disease Years Before Clinical Diagnosis
Objective: To evaluate longitudinal prospective progression from gait and mobility data from individuals who were later diagnosed with PD. Background: Diagnosis of clinical Parkinson's disease…Low-Intensity Treadmill Training Preserves Motor Function and Muscle Mass Through Mitochondrial and Antioxidant Regulation in a Rat Model of Parkinson’s Disease
Objective: To identify an exercise regimen with the greatest neuroprotective benefit in Parkinson’s disease (PD) and determine whether low-intensity treadmill training preserves motor function and…A Rare Case of PLA2G6 Gene Related Early-Onset Dystonia-Parkinsonism; What Not to Miss Clinically and Radiologically
Objective: PLA2G6-associated neurodegeneration (PLAN) is a rare form of neurodegeneration with brain iron accumulation (NBIA) leading to heterogeneous clinical manifestation including infantile neuroaxonal dystrophy, atypical…Prevalence of drooling in Parkinson’s disease: a multi-center observational study
Objective: This study investigated the prevalence of drooling and related factors. Background: The prevalence of drooling in Parkinson's disease (PD) varies widely, from 10% to…Establishing the Ukrainian Parkinson’s Disease Cohort within GP2: Early Results from the UPGRADE-PD Initiative
Objective: To describe the early establishment and recruitment outcomes of the Ukrainian Parkinson’s disease cohort within the Global Parkinson’s Genetics Program (GP2). Background: Eastern European…Real-World Mobility Measures Reveal Early Indicators of Parkinson’s Disease Risk in Older Women
Objective: To evaluate cost-effective, interpretable methods for identifying elevated risk for Parkinson’s disease using real-world wearable accelerometry and self-reported health data. Background: Mobility changes may emerge…Comprehensive large-scale analysis of gene-environment interactions in Parkinson’s disease
Objective: This study aims to comprehensively explore the gene-environment interactions in PD using the large-scale UK Biobank dataset. Background: Parkinson's disease (PD) is a neurodegenerative…Electroencephalographic and Functional Magnetic Resonance Imaging Analysis of Daytime Sleepiness in Parkinson’s Disease
Objective: To explore the electroencephalographic (EEG) characteristics and brain functional connectivity patterns in Parkinson's disease (PD) patients with daytime sleepiness. Background: Daytime sleepiness is a…
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